We read with great interest the article entitled “Efficacy of citalopram on stroke recurrence: A randomized clinical trial” conducted by Çetin E. et al. [
]. This randomized clinical trial, in which 440 patients were enrolled, revealed a significant relationship between depression treatment and recurrent stroke and patients whose depression did not respond well to citalopram had 2.5 times higher chance of stroke recurrence than the patients with remitting depression. Additionally, other vascular risk factors (e.g. hypertension, atrial fibrillation, etc.) were shown as predictors of stroke recurrence based on multivariable analysis. This study could add valuable pieces to the current evidence regarding stroke secondary prevention; however, some points exist in the aim, methods, results, and conclusion that should be addressed.
- Ece Çetin F.
- Kumral E.
- Saffet Gönül A.
- Nezih Özdemir H.
- Orman M.
Efficacy of citalopram on stroke recurrence: A randomized clinical trial.
J Clin Neurosci. 2022; 101: 168-174
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- Efficacy of citalopram on stroke recurrence: A randomized clinical trial.J Clin Neurosci. 2022; 101: 168-174
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Published online: February 23, 2023
Accepted: February 15, 2023
Received: February 8, 2023
Publication stageIn Press Corrected Proof
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