- •The use of a checklist improved protocol adherence for diagnosis of death by neurologic criteria/brain death and did not increase time to declaration of death.
- •Metabolic and toxic confounders are common to encounter in patients who progress to death by neurologic criteria/brain death.
- •The clinical diagnosis of death by neurologic criteria/brain death is commonly limited by the inability to complete apnea testing, and these cases require appropriate ancillary testing.
Classification of Evidence
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Ad Hoc Committee of the Harvard Medical School to Examine the Definition of Brain Death. A definition of irreversible coma: report of the Ad Hoc Committee of the Harvard Medical School to Examine the Definition of Brain Death. JAMA. 1968;205:337-340.
Defining Death: Medical, Legal and Ethical Issues in the Determination of Death [Internet]. Washington, DC: Georgetown University; 1981; available at: https://repository.library.georgetown.edu/bitstream/handle/10822/559345/defining_death.%20pdf?sequence=1. Accessed Nov 10, 2020.
- Variability in reported physician practices for Brain Death determination.Neurology. 2019; 92: e888-e894
- Practice variability in brain death determination: a call to action.Neurology. 2013; 81: 2009-2014
- Variability in diagnosing brain death at an academic medical center.Neurosci J. 2017; 2017: 1-7
- Diagnosis Brain Death: The importance of documenting clinical test results.Anaesthesia. 1999; 54: 81-83
- An evaluation of brainstem death documentation: the importance of full documentation.Pedia Anesthesia. 2004; 14: 584-588
- Brain Death documentation: analysis and issues.Neurosurgery. 2002; 51: 731-735
- Determination of death by neurological criteria round the world.Neurology. 2020; 95: e299-e309
Wijdicks EFM, Varelas PN, Gronseth GS, et al. Evidence-based guideline update: Determining brain death in adults. 2010;74(23):1911-8.
- Quality improvement in neurology: Inpatient and emergency care quality set.Neurology. 2017; 89: 730-735
SL Schafer. StanpumpR. Available at <stanpumpr.io>. Copyright 2019. Accessed on Feb. 4 2021.
- Society for Endocrinology Clinical Guidance: Inpatient management of cranial diabetes insipidus.Endocr Connect. 2018; 7: G8-G11
- Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group.Crit Care. 2004; 8: R204-R212
- ACG clinical guideline: evaluation of abnormal liver chemistries.Am J Gastroenterol. 2017; 112: 18-35
- Clinical biostatistics. LIV. The biostatistics of concordance.Clin Pharmcol Ther. 1981; 29: 111-123
- Outcomes and implications of a single brain death exam policy on organ donation outcomes at a high-volume trauma center.J Trauma Acute Care Surg. 2020;
- Safe Surgery Saves Lives study Group. A surgical safety checklist to reduce morbidity and mortality in a global population. N Eng.J Med. 2009; 360: 491-499
- An intervention to decrease catheter related bloodstream infections in the ICU.N Engl J Med. 2006; 355: 2725-2732
- SURPASS Collaborative Group. Effect of a comprehensive surgical safety system on patient outcomes.N Engl J Med. 2010; 363: 1928-1937