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Elevated ApoB/ApoA-Ι ratio is associated with poor outcome in acute ischemic stroke

Published:November 16, 2022DOI:https://doi.org/10.1016/j.jocn.2022.11.007

      Highlights

      • Higher ApoB, lower ApoA-Ι, higher ApoB/ApoA-Ι ratio were independently associated with poor outcome in acute ischemic stroke.
      • ApoB and ApoA-Ι were not related to the transformation of intracranial hemorrhage in acute ischemic stroke.
      • ApoB/ApoA-Ι ratio was more likely associated with poor outcomes of AIS in the patients of small artery occlusion.

      Abstract

      Background

      Apolipoproteins are known atherogenic factors that play important roles in many mechanisms related to acute ischemic stroke (AIS). However, it is unclear whether the ApoB/ApoA-Ι ratio is related to the prognosis of patients with AIS.

      Methods

      We conducted a prospective cohort study in the Department of Neurology, Yangpu Hospital, School of Medicine, Tongji University and investigated the association between ApoB/ApoA-Ι ratio and poor outcomes at 3 months of AIS.

      Results

      1,247 patients that met the eligibility criteria were enrolled in our study. We found that ApoA-Ι (Adjusted odds ratios (adjOR) 0.529, 95 %CI 0.327–0.855), ApoB (adjOR 3.015, 95 %CI 1.746–5.207), and ApoB/ApoA-Ι ratio (adjOR 3.986, 95 %CI 2.220–7.155) were independently associated with poor outcomes in acute ischemic stroke. During subgroup analysis, the ApoB/ApoA-Ι ratio was more likely associated with poor AIS outcomes in males and patients younger than 80 with SAO(Small Artery Occlusion) and no history of diabetes or statin use. Restricted cubic spline analyses explored the correlation between poor outcomes and ApoB/ApoA-Ι ratio.

      Conclusions

      Higher ApoB, lower ApoA-Ι, and higher ApoB/ApoA-Ι ratios were independently associated with poor outcomes in AIS. However, ApoB and ApoA-Ι were not related to hemorrhagic transformation in AIS.

      Keywords

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