Highlights
- •Higher ApoB, lower ApoA-Ι, higher ApoB/ApoA-Ι ratio were independently associated with poor outcome in acute ischemic stroke.
- •ApoB and ApoA-Ι were not related to the transformation of intracranial hemorrhage in acute ischemic stroke.
- •ApoB/ApoA-Ι ratio was more likely associated with poor outcomes of AIS in the patients of small artery occlusion.
Abstract
Background
Apolipoproteins are known atherogenic factors that play important roles in many mechanisms
related to acute ischemic stroke (AIS). However, it is unclear whether the ApoB/ApoA-Ι
ratio is related to the prognosis of patients with AIS.
Methods
We conducted a prospective cohort study in the Department of Neurology, Yangpu Hospital,
School of Medicine, Tongji University and investigated the association between ApoB/ApoA-Ι
ratio and poor outcomes at 3 months of AIS.
Results
1,247 patients that met the eligibility criteria were enrolled in our study. We found
that ApoA-Ι (Adjusted odds ratios (adjOR) 0.529, 95 %CI 0.327–0.855), ApoB (adjOR
3.015, 95 %CI 1.746–5.207), and ApoB/ApoA-Ι ratio (adjOR 3.986, 95 %CI 2.220–7.155)
were independently associated with poor outcomes in acute ischemic stroke. During
subgroup analysis, the ApoB/ApoA-Ι ratio was more likely associated with poor AIS
outcomes in males and patients younger than 80 with SAO(Small Artery Occlusion) and
no history of diabetes or statin use. Restricted cubic spline analyses explored the
correlation between poor outcomes and ApoB/ApoA-Ι ratio.
Conclusions
Higher ApoB, lower ApoA-Ι, and higher ApoB/ApoA-Ι ratios were independently associated
with poor outcomes in AIS. However, ApoB and ApoA-Ι were not related to hemorrhagic
transformation in AIS.
Keywords
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Article info
Publication history
Published online: November 16, 2022
Accepted:
November 11,
2022
Received:
July 6,
2022
Identification
Copyright
© 2022 Elsevier Ltd. All rights reserved.
