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Lactate dehydrogenase-to albumin ratio (LAR) is associated with early-onset cognitive impairment after acute ischemic stroke

  • Minjie Xu
    Affiliations
    Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China

    School of Mental Health, Wenzhou Medical University, Wenzhou 325000, China
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  • Zijing Wu
    Affiliations
    School of Mental Health, Wenzhou Medical University, Wenzhou 325000, China
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  • Beilan Wu
    Affiliations
    Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
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  • Yaoyao Hu
    Affiliations
    Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
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  • Qi Duan
    Affiliations
    Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
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  • Huali Wang
    Correspondence
    Corresponding authors at: Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China (J. He); School of Mental Health, Wenzhou Medical University, Wenzhou 325000, China; Dementia Care and Research Center, Beijing Dementia Key Lab, Peking University Institute of Mental Health (Sixth Hospital), Beijing 100191, China; NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100191, China. (H. Wang)
    Affiliations
    School of Mental Health, Wenzhou Medical University, Wenzhou 325000, China

    Dementia Care and Research Center, Beijing Dementia Key Lab, Peking University Institute of Mental Health (Sixth Hospital), Beijing 100191, China

    NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100191, China
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  • Jincai He
    Correspondence
    Corresponding authors at: Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China (J. He); School of Mental Health, Wenzhou Medical University, Wenzhou 325000, China; Dementia Care and Research Center, Beijing Dementia Key Lab, Peking University Institute of Mental Health (Sixth Hospital), Beijing 100191, China; NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100191, China. (H. Wang)
    Affiliations
    Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
    Search for articles by this author

      Highlights

      • Cognitive impairment occurred in a considerable number of patients after stroke.
      • The patients with cognitive impairment after stroke showed higher LAR levels.
      • LAR was independently related to post-stroke cognitive impairment.

      Abstract

      Background

      Post-stroke cognitive impairment (PSCI) is the most prevalent complication of acute ischemic stroke(AIS) in individuals. The lactate dehydrogenase-to albumin ratio (LAR) is a novel indicator that measures systemic inflammation and nutritional status. The purpose of this research was to investigate the connection between the LAR and PSCI.

      Methods

      Following inclusion criteria, this study recruited 701 AIS patients who were segmented into the PSCI (n = 441) and non-PSCI (n = 260) groups according to the Mini-Mental State Examination (MMSE) within 2 weeks after stroke. The lactate dehydrogenase and albumin levels were measured within 24 h after hospitalization. A binary logistic regression was constructed to examine the association between LAR and PSCI with the LAR divided into tertiles.

      Results

      The PSCI group showed a higher level of LAR in comparison to the non-PSCI group (p < 0.001). Compared with T1 (≦4.93), patients in the highest quartile of LAR (≧5.93) had a greater risk of PSCI after controlling for confounding factors, as demonstrated by logistic regression (odds ratio (OR) = 2.003, 95 % confidence interval (CI) = 1.305–3.074, P = 0.001).

      Conclusion

      Higher LAR is independently related to the development of cognitive impairment in the early phase after stroke, which may help physicians in the early identification of patients with PSCI.

      Keywords

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