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High fibrinogen to albumin ratio is associated with hematoma enlargement in spontaneous intracerebral hemorrhage

  • Author Footnotes
    1 These authors contributed equally to this work.
    Qiongzhang Wang
    Footnotes
    1 These authors contributed equally to this work.
    Affiliations
    Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China
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  • Author Footnotes
    1 These authors contributed equally to this work.
    Yujie Tu
    Footnotes
    1 These authors contributed equally to this work.
    Affiliations
    Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China
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  • Yezhi Huang
    Affiliations
    Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China
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  • Liuzhu Chen
    Affiliations
    Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China
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  • Yisi Lin
    Affiliations
    Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China
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  • Luqian Zhan
    Affiliations
    Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China
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  • Jincai He
    Correspondence
    Corresponding author at: Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, People’s Republic of China.
    Affiliations
    Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China
    Search for articles by this author
  • Author Footnotes
    1 These authors contributed equally to this work.

      Highlights

      • HE often predicts a poor prognosis in patients with sICH.
      • The relationship between FAR and sICH or HE is still unclear.
      • Highest FAR tertile was independently associated with HE.
      • High FAR level may be beneficial to early predict patients with HE.

      Abstract

      Background

      We investigate whether fibrinogen to albumin ratio could predict hematoma enlargement in patients suffered with spontaneous intracerebral hemorrhage.

      Materials and methods

      A total of 149 patients met the entry criteria and received 1-month follow-up after discharge were divided into tertiles based on fibrinogen to albumin ratio levels (Tertile 1 [<8.06], Tertile 2 [8.06–10.33], Tertile 3 [>10.33]). Univariate analysis and binary logistic regression analysis was performed to explore the relationship between fibrinogen to albumin ratio and hematoma enlargement occurrence.

      Results

      There was a significant difference in fibrinogen to albumin ratio between hematoma enlargement group and non-hematoma enlargement group (10.11 (8.37–11.73) vs 8.81 (7.61–10.39), p = .017). In binary logistic regression analysis, the highest tertile (>10.33) was independently related to hematoma enlargement (OR = 3.152, 95% CI = 1.326–7.493, p = .009).

      Conclusion

      Fibrinogen to albumin ratio on admission might be an independent predictor of hematoma enlargement after intracerebral hemorrhage.

      Abbreviations:

      FAR (fibrinogen to albumin ratio), FIB (fibrinogen), ALB (albumin), HE (hematoma enlargement), sICH (spontaneous intracerebral hemorrhage), IRB (Institutional Review Board), CT (computerized tomography), BBB (blood–brain barrier), AST (alanine transaminase), ALT (aspartate transaminase), HDL‐C (high ‐density lipoprotein‐cholesterol), LDL‐C (low‐density lipoprotein‐cholesterol), Cr (creatinine), SBP (systolic blood pressure), DBP (diastolic blood pressure), NIHSS (National Institutes of Health Stroke Scale), mRS (modified Rankin Scale), ORs (odds ratios), CIs (confidence intervals)

      Keywords

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