Highlights
- •The relationship between serum calcium and hemorrhagic transformation remains controversial.
- •We conducted a meta-analysis to explore the relationship between serum calcium and hemorrhagic transformation.
- •The results of this study may provide a basis for the prevention of hemorrhagic transformation.
- •Serum calcium was related to hemorrhagic transformation and may be one of the risk factors for hemorrhagic transformation.
Abstract
Background
Hemorrhagic transformation (HT) is a common complication of ischemic stroke. A growing
number of studies have found that serum calcium levels are lower in HT groups than
in control groups. However, the relationship between serum calcium and HT remains
controversial. We performed a meta-analysis to assess the relationship between serum
calcium levels and HT.
Methods and results
Electronic databases were searched for studies on serum calcium and HT from inception
to November 6, 2021. Ten studies included in present meta-analysis with a total of
3212 participants. Due to the high heterogeneity (I2 = 81%), we chose the random effects model. The results showed that the serum calcium
level in the HT group was significantly lower than that in the control group (pooled
mean difference, −0.05; 95% confidence interval (CI), (−0.09, −0.02); P = 0.001).
Whether thrombolytic or not the results were applied (pooled mean difference, −0.07;
95% CI, (−0.13, −0.01); P = 0.02 and pooled mean difference, −0.03; 95% CI, (−0.06,
−0.01); P = 0.007).
Conclusions
Serum calcium was related to HT and may be one of the risk factors for HT.
Keywords
Abbreviations:
AIS (acute ischemic stroke), asICH (asymptomatic intracranial hemorrhage), CBM (Chinese Biomedical Literature Database), CI (confidence interval), CNKI (China National Knowledge Infrastructure), CT (computed tomography), EVT (endovascular treatment), HT (hemorrhagic transformation), IVT (intravenous thrombolysis), MRI (magnetic resonance imaging), NA (not available), NOS (Newcastle Ottawa Scale), PRISMA (Preferred Reporting Items for Systematic Reviews and meta-Analyses)To read this article in full you will need to make a payment
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Article info
Publication history
Accepted:
August 4,
2022
Received:
January 18,
2022
Identification
Copyright
© 2022 Elsevier Ltd. All rights reserved.
