- •Cytotoxic lesions of the corpus callosum (CLOCCs) can manifest in a wide variety of systemic infections including Coxiella Burnetii.
- •CLOCCs, in rare cases, also manifest in response to seizure activity, medications, haemorrhage, neoplasm and metabolic disturbance.
- •Differentials for CLOCCs include Marchiafava-Bignami disease, stroke, lymphoma and glioblastoma.
Abbreviations:CLOCC (Cytotoxic lesion of the Corpus Callosum), FLAIR (FLuid Attenuated Inverse Recovery), DWI (Diffusion weighted Imaging), ADC (Apparent Diffusion Coefficient)
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
- Cytotoxic Lesions of the Corpus Callosum That Show Restricted Diffusion: Mechanisms, Causes, and Manifestations.RadioGraphics. 2017; 37: 562-576
- COVID-19-Associated Cytotoxic Lesions of the Corpus Callosum.AJNR Am J Neuroradiol. 2020; 41: 1905-1907
Bulakbasi N, Kocaoglu M, Tayfun C, Ucoz T. Transient Splenial Lesion of the Corpus Callosum in Clinically Mild Influenza-Associated Encephalitis/Encephalopathy. Am J Neuroradiol 2006;27(9):1983–1986.
- Acute cerebellitis caused by Coxiella burnetii.Ann Neurol. 1999; 45: 124-127
- Neurological Involvement in Acute Q Fever: A Report of 29 Cases and Review of the Literature.Arch Intern Med. 2002; 162: 693