Cytotoxic lesion of the corpus callosum in a case of Q fever


      • Cytotoxic lesions of the corpus callosum (CLOCCs) can manifest in a wide variety of systemic infections including Coxiella Burnetii.
      • CLOCCs, in rare cases, also manifest in response to seizure activity, medications, haemorrhage, neoplasm and metabolic disturbance.
      • Differentials for CLOCCs include Marchiafava-Bignami disease, stroke, lymphoma and glioblastoma.


      CLOCC (Cytotoxic lesion of the Corpus Callosum), FLAIR (FLuid Attenuated Inverse Recovery), DWI (Diffusion weighted Imaging), ADC (Apparent Diffusion Coefficient)
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Journal of Clinical Neuroscience
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Starkey J.
        • Kobayashi N.
        • Numaguchi Y.
        • Moritani T.
        Cytotoxic Lesions of the Corpus Callosum That Show Restricted Diffusion: Mechanisms, Causes, and Manifestations.
        RadioGraphics. 2017; 37: 562-576
        • Gaur P.
        • Dixon L.
        • Jones B.
        • Lyall H.
        • Jan W.
        COVID-19-Associated Cytotoxic Lesions of the Corpus Callosum.
        AJNR Am J Neuroradiol. 2020; 41: 1905-1907
      1. Bulakbasi N, Kocaoglu M, Tayfun C, Ucoz T. Transient Splenial Lesion of the Corpus Callosum in Clinically Mild Influenza-Associated Encephalitis/Encephalopathy. Am J Neuroradiol 2006;27(9):1983–1986.

        • Sawaishi Y.
        • Takahashi I.
        • Hirayama Y.
        • Abe T.
        • Mizutani M.
        • Hirai K.
        • et al.
        Acute cerebellitis caused by Coxiella burnetii.
        Ann Neurol. 1999; 45: 124-127
        • Bernit E.
        • Pouget J.
        • Janbon F.
        • Dutronc H.
        • Martinez P.
        • Brouqui P.
        • et al.
        Neurological Involvement in Acute Q Fever: A Report of 29 Cases and Review of the Literature.
        Arch Intern Med. 2002; 162: 693