Advertisement

Evaluating the correlation between migraine and subclinical atherosclerosis

  • Author Footnotes
    1 Co-first Authors: The Co-Author 1 and the co-Author 2 have had equal contribution to this manuscript.
    Sara Esmaeili
    Footnotes
    1 Co-first Authors: The Co-Author 1 and the co-Author 2 have had equal contribution to this manuscript.
    Affiliations
    Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran

    School of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran

    Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
    Search for articles by this author
  • Author Footnotes
    1 Co-first Authors: The Co-Author 1 and the co-Author 2 have had equal contribution to this manuscript.
    Mohammadreza Alizadeh
    Footnotes
    1 Co-first Authors: The Co-Author 1 and the co-Author 2 have had equal contribution to this manuscript.
    Affiliations
    Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran
    Search for articles by this author
  • Yasaman Abdi
    Affiliations
    Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
    Search for articles by this author
  • Sepideh Allahdadian
    Affiliations
    Pacific Parkinson's Research Centre, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada
    Search for articles by this author
  • Samira Chaibakhsh
    Affiliations
    Eye Research Center, The Five Senses Institute Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
    Search for articles by this author
  • Mahya Naderkhani
    Affiliations
    Trauma and Injury Research Center, Iran University of Medical Sciences, Tehran, Iran

    Department of Emergency Medicine, Rasool Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
    Search for articles by this author
  • Seyed Farzad Maroufi
    Affiliations
    Faculty of Medicine, Tehran University of Medical Sciences, Iran
    Search for articles by this author
  • Forough Baharvand
    Correspondence
    Corresponding authors at: Zahra Mirzaasgari, Assistant Professor of Neurology, Iran University of Medical Sciences, Tehran, Iran and Forough Baharvand, Iran University of Medical Sciences, Tehran, Iran.
    Affiliations
    Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
    Search for articles by this author
  • Zahra Mirzaasgari
    Correspondence
    Corresponding authors at: Zahra Mirzaasgari, Assistant Professor of Neurology, Iran University of Medical Sciences, Tehran, Iran and Forough Baharvand, Iran University of Medical Sciences, Tehran, Iran.
    Affiliations
    Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
    Search for articles by this author
  • Mohammad Taghi Joghataei
    Affiliations
    Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran

    School of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
    Search for articles by this author
  • Author Footnotes
    1 Co-first Authors: The Co-Author 1 and the co-Author 2 have had equal contribution to this manuscript.

      Highlights

      • Migraine is known to be associated with vascular dysfunction.
      • However, sufficient evidence has not been reported in this regard.
      • Migraine and its related medications do not affect vascular changes in favor of atherosclerosis.
      • These findings might be valid for patients with acute migraines only.

      Abstract

      Backgrounds and aims

      Migraine is known to be associated with vascular dysfunction. However, sufficient evidence has not been reported in this regard. This study aims to assess subclinical atherosclerosis and endothelial function via Doppler Sonography in migraine patients.

      Methods

      In this case control study, Subjects were divided into two groups; Patients with migraine, and Healthy controls. Migraine was diagnosed according to the International Classification of Headache Disorders criteria. Participants were evaluated for carotid intima-media thickness (IMT) and flow-mediated dilation (FMD) indices, and the findings were compared between the two groups.

      Results

      In the study population, 64.9 % were female, and the mean age was 34.63 ± 6.06 years. Of the 47 people with migraine, 12 suffered from migraine with aura. Increased IMT was more in migraine with and without aura compared to control (p = 0.247), and FMD was lower in these groups than the control group (p = 0.311). There was a significant correlation between the duration of headache with the duration of migraine (p = 0.007, 0.389) and IMT (p = 0.038, 0.303). No statistically significant differences were observed between NSAID, acetaminophen, and ergotamine groups with IMT (p = 0.532) and FMD (p = 0.834).

      Conclusion

      Migraine and its related medications do not affect vascular changes in favor of atherosclerosis. However, these findings might be valid for patients with acute migraines only.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of Clinical Neuroscience
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Linstra K.M.
        • Ibrahimi K.
        • Terwindt G.M.
        • Wermer M.J.
        • MaassenVanDenBrink A.
        Migraine and cardiovascular disease in women.
        Maturitas. 2017; 97: 28-31
        • Larsen J.S.
        • Skaug E.-A.
        • Wisløff U.
        • Ellingsen Ø.
        • Stovner L.J.
        • Linde M.
        • et al.
        Migraine and endothelial function: The HUNT3 Study.
        Cephalalgia. 2016; 36: 1341-1349
        • Schwaag S.
        • Nabavi D.G.
        • Frese A.
        • Husstedt I.W.
        • Evers S.
        The association between migraine and juvenile stroke: a case-control study.
        Headache. 2003; 43: 90-95
        • Scher A.I.
        • Terwindt G.M.
        • Picavet H.S.
        • Verschuren W.M.
        • Ferrari M.D.
        • Launer L.J.
        Cardiovascular risk factors and migraine: the GEM population-based study.
        Neurology. 2005; 64: 614-620
        • Poyrazoglu H.G.
        • Vurdem U.E.
        • Arslan A.
        • Uytun S.
        Evaluation of carotid intima-media thickness in children with migraine: a marker of subclinical atherosclerosis.
        Neurol Sci. 2016; 37: 1663-1669
        • Sarchielli P.
        • Alberti A.
        • Baldi A.
        • Coppola F.
        • Rossi C.
        • Pierguidi L.
        • et al.
        Proinflammatory cytokines, adhesion molecules, and lymphocyte integrin expression in the internal jugular blood of migraine patients without aura assessed ictally.
        Headache. 2006; 46: 200-207
        • Martami F.
        • Razeghi Jahromi S.
        • Togha M.
        • Ghorbani Z.
        • Seifishahpar M.
        • Saidpour A.
        The serum level of inflammatory markers in chronic and episodic migraine: a case-control study.
        Neurol Sci. 2018; 39: 1741-1749
        • Hamed S.A.
        • Hamed E.A.
        • Ezz Eldin A.M.
        • Mahmoud N.M.
        Vascular Risk Factors, Endothelial Function, and Carotid Thickness in Patients with Migraine: Relationship to Atherosclerosis.
        J Stroke Cerebrovasc Dis. 2010; 19: 92-103
        • Mason B.N.
        • Russo A.F.
        Vascular Contributions to Migraine: Time to Revisit?.
        Front Cell Neurosci. 2018; 12
        • Toth P.P.
        Subclinical atherosclerosis: what it is, what it means and what we can do about it.
        Int J Clin Pract. 2008; 62: 1246-1254
        • Adelborg K.
        • Szépligeti S.K.
        • Holland-Bill L.
        • Ehrenstein V.
        • Horváth-Puhó E.
        • Henderson V.W.
        • et al.
        Migraine and risk of cardiovascular diseases: Danish population based matched cohort study.
        BMJ. 2018; 360
        • Paul J.
        • Shaw K.
        • Dasgupta S.
        • Ghosh M.K.
        Measurement of intima media thickness of carotid artery by B-mode ultrasound in healthy people of India and Bangladesh, and relation of age and sex with carotid artery intima media thickness: An observational study.
        J Cardiovasc Dis Res. 2012; 3: 128-131
        • Vernieri F.
        • Moro L.
        • Altamura C.
        • Palazzo P.
        • Antonelli Incalzi R.
        • Rossini P.M.
        • et al.
        Patients with migraine with aura have increased flow mediated dilation.
        BMC Neurol. 2010; 10: 18
        • Avci A.Y.
        • Akkucuk M.H.
        • Torun E.
        • Arikan S.
        • Can U.
        • Tekindal M.A.
        Migraine and subclinical atherosclerosis: endothelial dysfunction biomarkers and carotid intima-media thickness: a case-control study.
        Neurol Sci. 2019; 40: 703-711
        • Sabri M.R.
        • Dehghan B.
        • Yaghini O.
        • Nasiri J.
        • Mansourian M.
        • Khalifehsoltani S.
        Endothelial dysfunction state in migraine headache and neutrally mediated syncope in children and young adults.
        J Res Med Sci. 2015; 20: 771-776
        • Yilmaz Avci A.
        • Akkucuk M.H.
        • Torun E.
        • Arikan S.
        • Can U.
        • Tekindal M.A.
        Migraine and subclinical atherosclerosis: endothelial dysfunction biomarkers and carotid intima-media thickness: a case-control study.
        Neurol Sci. 2019; 40: 703-711
        • Georgescu D.
        • Iurciuc M.S.
        • Ionita I.
        • Dragan S.
        • Muntean M.
        • Ancusa O.E.
        • et al.
        Migraine without Aura and Subclinical Atherosclerosis in Young Females: Is Gut Microbiota to Blame?.
        Medicina. 2019; 55: 786
        • van Os H.J.A.
        • Mulder I.A.
        • Broersen A.
        • Algra A.
        • van der Schaaf I.C.
        • Kappelle L.J.
        • et al.
        Migraine and Cerebrovascular Atherosclerosis in Patients With Ischemic Stroke.
        Stroke. 2017; 48: 1973-1975
      1. Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018;38(1):1-211.

        • Rossato A.
        • Veronese F.
        • Maggioni F.
        • Vedovetto V.
        • Zancan A.
        • Biasiolo M.
        • et al.
        Autonomic dysfunction and endothelial changes in migraine sufferers.
        Panminerva Med. 2011; 53: 13-18
        • Goulart A.C.
        • Santos I.S.
        • Bittencourt M.S.
        • Lotufo P.A.
        • Benseñor I.M.
        Migraine and subclinical atherosclerosis in the Brazilian longitudinal study of adult health (ELSA-Brasil).
        Cephalalgia. 2016; 36: 840-848
        • Wang Q.
        • Liu Z.-Y.
        • Zhou J.
        Ultrasonic assessment of carotid intima-media thickness in migraine: a meta-analysis.
        J Int Med Res. 2019; 47: 2848-2855
        • González-Quintanilla V.
        • Toriello M.
        • Palacio E.
        • González-Gay M.A.
        • Castillo J.
        • Montes S.
        • et al.
        Systemic and cerebral endothelial dysfunction in chronic migraine. A case-control study with an active comparator.
        Cephalalgia. 2016; 36: 552-560
        • Perko D.
        • Pretnar-Oblak J.
        • Sabovic M.
        • Zvan B.
        • Zaletel M.
        Endothelium-dependent vasodilatation in migraine patients.
        Cephalalgia. 2011; 31: 654-660