Advertisement

The diagnostic signature of Susac’s syndrome

  • Todd A. Hardy
    Correspondence
    Address: Neuroimmunology Clinic, Concord Repatriation General Hospital, University of Sydney, Australia.
    Affiliations
    Neuroimmunology Clinic, Concord Repatriation General Hospital, University of Sydney, Australia

    Brain & Mind Centre, University of Sydney, NSW, Australia
    Search for articles by this author

      Highlights:

      • Susac’s syndrome is frequently misdiagnosed.
      • Callosal snowballs are best seen on sagittal FLAIR MRI brain sequences.
      • Fundus fluorescein angiography (FFA) is vital for diagnosis.
      • Early diagnosis and treatment may limit end-organ damage.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of Clinical Neuroscience
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Marrodan M.
        • Fiol M.P.
        • Correale J.
        Susac syndrome: challenges in the diagnosis and treatment.
        Brain. 2022; 145: 858-871
        • Triplett J.D.
        • Qiu J.
        • O'Brien B.
        • Gopinath S.
        • Trewin B.
        • Spring P.J.
        • et al.
        Diagnosis, differential diagnosis and misdiagnosis of Susac syndrome.
        Eur J Neurol. 2022; 29: 1771-1781
        • Garg N.
        • Reddel S.W.
        • Miller D.H.
        • Chataway J.
        • Riminton D.S.
        • Barnett Y.
        • et al.
        The corpus callosum in the diagnosis of multiple sclerosis and other CNS demyelinating and inflammatory diseases.
        J Neurol Neurosurg Psychiatry. 2015; 86: 1374-1382
        • Susac J.O.
        • Murtagh F.R.
        • Egan R.A.
        • Berger J.R.
        • Bakshi R.
        • Lincoff N.
        • et al.
        MRI findings in Susac's syndrome.
        Neurology. 2003; 61: 1783-1787
        • Hardy T.A.
        • Taylor R.L.
        • Qiu J.
        • O'Brien B.
        • Gopinath S.
        • Trewin B.
        • et al.
        The neuro-otology of Susac syndrome.
        J Neurol. 2020; 267: 3711-3722
        • Triplett J.D.
        • Buzzard K.A.
        • Lubomski M.
        • Riminton D.S.
        • Barnett M.H.
        • Welgampola M.S.
        • et al.
        Immune-mediated conditions affecting the brain, eye and ear (BEE syndromes).
        J Neurol Neurosurg Psychiatry. 2019; 90: 882-894