Highlights
- •A prospective, observational, cross-sectional cohort study for Parkinson's disease.
- •Serum 25(OH)D associated with cognitive impairment in Parkinson's disease patients.
- •Serum 25(OH)D is a biomarker of cognitive impairment in Parkinson's disease.
Abstract
This study aimed to investigate the relationship between serum 25(OH)D and cognitive
impairment in patients with Parkinson's disease (PD), hoping to provide possible ideas
for the diagnosis and prevention of PD with cognitive impairment. Vitamin D is a neurosteroid
with neurotrophic and neuroprotective functions, playing an important role in PD and
its progression. In the present study, serum 25(OH)D levels were significantly decreased
in PD patients (45.86 ± 14.81 nmol/L)compared to healthy controls(56.54 ± 14.00 nmol/L)
(P < 0.001), and significant differences were also observed in PD patients with normal
cognition (PD-NC), PD patients with mild cognitive impairment (PD-MCI)and PD patients
with dementia (PDD)(P < 0.05). Moreover, there was a positive correlation between serum 25(OH)D levels
and Montreal cognitive assessment(MoCA) scores (r = 0.489,P < 0.001).The increased serum 25(OH)D was an independent protective factor of cognitive
impairment in PD (OR = 0. 949, P = 0.005), and the sensitivity, specificity, and AUC under the ROC curve area of serum
25(OH)D were 53.3%, 86.5%, and 0.713, respectively. These findings support the relationship
between cognitive impairment and Vitamin D in PD patients. Serum 25(OH)D may be a
useful biomarker for diagnosing cognitive impairment in patients with PD.
Keywords
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Article info
Publication history
Accepted:
April 14,
2022
Received:
February 15,
2022
Identification
Copyright
© 2022 Elsevier Ltd. All rights reserved.
