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Reorganization of auditory-visual network interactions in long-term unilateral postlingual hearing loss

  • Author Footnotes
    1 These authors contributed equally to this work.
    Zixuan Wei
    Footnotes
    1 These authors contributed equally to this work.
    Affiliations
    Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, China
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  • Author Footnotes
    1 These authors contributed equally to this work.
    Zhen Fan
    Footnotes
    1 These authors contributed equally to this work.
    Affiliations
    Neurosurgical Institute of Fudan University, China
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  • Zengxin Qi
    Affiliations
    Shanghai Clinical Medical Center of Neurosurgery, China
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  • Yusheng Tong
    Affiliations
    Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, China

    Neurosurgical Institute of Fudan University, China

    Shanghai Clinical Medical Center of Neurosurgery, China
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  • Qinglong Guo
    Affiliations
    Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, China

    Neurosurgical Institute of Fudan University, China

    Shanghai Clinical Medical Center of Neurosurgery, China
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  • Liang Chen
    Correspondence
    Corresponding author at: Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Neurosurgical Institute of Fudan University, Shanghai Clinical Medical Center of Neurosurgery, No. 12 Mid Wulumuqi Rd, Shanghai 200040, China.
    Affiliations
    Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, China

    Neurosurgical Institute of Fudan University, China

    Shanghai Clinical Medical Center of Neurosurgery, China
    Search for articles by this author
  • Author Footnotes
    1 These authors contributed equally to this work.

      Highlights

      • Long-term UHI could increase interactions of the auditory-visual networks.
      • The DC of the audiovisual networks is positively related to the hearing loss degree.
      • The audiovisual networks changed more on the affected side of UHI patients.

      Abstract

      Long-term unilateral hearing loss could reorganize the functional network association between the bilateral auditory cortices, while alterations of other functional networks need to be further explored. We attempted to investigate the pattern of the reorganization of functional network associations between the auditory and visual cortex caused by long-term postlingual unilateral hearing loss (UHI) and its relationship with clinical characteristics. Therefore, 48 patients with hearing loss caused by unilateral acoustic tumors and 52 matched healthy controls were enrolled, and their high-resolution structural MRI and resting-state functional MRI data were also collected to depict the brain network. Degree centrality (DC) was employed to evaluate the functional network association of the auditory-visual network interaction. Group comparisons were performed to investigate the network reorganization, and its correlations with clinical data were calculated. Compared with the healthy control group, patients with UHI showed significantly increased DC between the auditory network (superior temporal gyrus and the medial geniculate body) and the visual network. Meanwhile, this difference was positively correlated with the extent of hearing impairment, and the correlation was more significant with the ipsilateral superior temporal gyrus in cases of acoustic neuroma. These results suggest that long-term unilateral hearing impairment may lead to enhancement of the visual-auditory network interactions and that the degree of reorganization is positively correlated with the pure tone average (PTA) and is more significant for the ipsilateral superior temporal gyrus, which provides clinical evidence regarding cross-modal plasticity in the UHI and its lateralization.

      Abbreviations:

      DC (degree centrality), UHI (unilateral hearing impairment), PTA (pure tone average), R-fMRI (resting-state functional magnetic resonance), RSFC (resting state functional connection), VN (visual network), SNHL (sensorineural hearing loss), MNI (Montreal Neurological Institute), GM (gray matter), WM (white matter), CSF (cerebrospinal fluid), FD (framewise displacement), FEW (familywise error), L-STG (left superior temporal gyrus), R-STG (right superior temporal gyrus), VMHC (voxel-mirrored homotopic connectivity), SSD (single-sided deafness), RHI (right hearing impairment), LHI (left hearing impairment), ICA (independent components analysis), PET (positron emission tomography)

      Keywords

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