Advertisement

High prevalence of developmental venous anomaly in adult patients with midline thalamic diffuse gliomas

      Highlights

      • The incidence of DVA in thalamic glioma was 18.18%.
      • Some phenotypic coexpression of shared gene may modulate the development of DVA.
      • Markers such as IDH1 were not associated with the development of DVA.

      Abstract

      Objective

      This study aimed to assess the prevalence of developmental venous anomaly (DVA) in patients with thalamic glioma. Furthermore, we explored the association between DVA and some important biomarkers, such as IDH1 mutation, and H3K27M mutation.

      Patients and Methods

      Patients who received tumor resection in West China Hospital between August 2009 and October 2017 were enrolled. Propensity score matching was conducted based on a logistic regression model and 1:1 matching for case and control was used to generate a new cohort from patients with meningioma. Chi-square test, t-test, univariate and multivariate analyses were employed to assess the prevalence of DVA in thalamic glioma and meningioma and to identify risk factors associated with DVA.

      Results

      Ninety-nine patients with thalamic glioma were enrolled in the current study (male, n = 54; female, n = 45). The mean age was 42.9 ± 15.3 years old. We identified a higher prevalence of DVA in 99 patients with thalamic glioma when compared with 99 patients with meningioma (18.18% vs. 7.07%), which was slightly lower than the prevalence of DVA in glioma reported in previous studies. Furthermore, the distribution of gender, age, and tumor grade in DVA did not reach statistical significance. Chi-square test, univariate and multivariate analyses showed that IDH1 mutation, ATRX mutation, MGMT promoter methylation, p53 mutation, MMP9, EGFR, and Top II positive expression, TERT mutation, and H3K27M mutation were not associated with the development of DVA in thalamic glioma.

      Conclusion

      A higher prevalence of DVA was found in thalamic glioma compared with meningioma.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of Clinical Neuroscience
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Tovi D.
        • Schisano G.
        • Liljeqvist B.
        Primary tumors of the region of the thalamus.
        J Neurosurg. 1961;
        • Mckissock W.
        • Paine K.W.E.
        Primary tumours of the thalamus.
        Brain. 1958;
        • Li Z.
        • Wu H.
        • Wu B.
        • et al.
        Long term follow-up and outcomes in adult patients with thalamic gliomas.
        Clin Neurol Neurosurg. 2020; 195: 105888
        • Niu X.
        • Wang T.
        • Zhou X.
        • et al.
        Surgical treatment and survival outcome of patients with adult thalamic glioma: a single institution experience of 8 years.
        J Neurooncol. 2020; 147: 377-386
        • Sarwar M.
        • Mccormick W.F.
        Intracerebral venous angioma: case report and review.
        Arch Neurol. 1978;
        • Aoki R.
        • Srivatanakul K.
        Developmental venous anomaly: benign or not benign.
        Neurol Med Chir. 2016;
        • Ruíz D.S.M.
        • Yilmaz H.
        • Gailloud P.
        Cerebral developmental venous anomalies.
        Curr Concepts. 2009;
        • Pereira V.M.
        • Geibprasert S.
        • Krings T.
        • et al.
        Pathomechanisms of symptomatic developmental venous anomalies.
        Stroke. 2008; 39: 3201-3215
        • Roux A.
        • Boddaert N.
        • Grill J.
        • et al.
        High prevalence of developmental venous anomaly in diffuse intrinsic pontine gliomas: a pediatric control study.
        Neurosurgery. 2019;
        • Jones B.V.
        • Linscott L.
        • Koberlein G.
        • Hummel T.R.
        • Leach J.L.
        Increased prevalence of developmental venous anomalies in children with intracranial neoplasms.
        Am J Neuroradiol. 2015;
        • Roux A.
        • Edjlali M.
        • Porelli S.
        • et al.
        Developmental venous anomaly in adult patients with diffuse glioma: a clinically relevant coexistence?.
        Neurology. 2019;
        • You G.
        • Sha Z.Y.
        • Yan W.
        • et al.
        Seizure characteristics and outcomes in 508 Chinese adult patients undergoing primary resection of low-grade gliomas: a clinicopathological study.
        Neuro-Oncology. 2012;
        • Chen N.
        • Yu T.
        • Gong J.
        • et al.
        IDH1/2 gene hotspot mutations in central nervous system tumours: analysis of 922 Chinese patients.
        Pathology. 2016; 48: 675-683
        • Mallmann A.L.
        • Arend L.S.
        • Oliveira G.S.
        • et al.
        Ce Pt E D an Us Cr Ip T Pt E D Us Cr T. 2020; 1–10
        • Liu J.
        • Zhang X.
        • Yan X.
        • Sun M.E.I.
        • Fan Y.
        • Huang Y.
        Significance of TERT and ATRX mutations in glioma.
        Oncol Lett. 2019; 17: 95-102
        • Huang T.Y.
        • Piunti A.
        • Lulla R.R.
        • et al.
        Detection of Histone H3 mutations in cerebrospinal fluid-derived tumor DNA from children with diffuse midline glioma.
        Acta Neuropathol Commun. 2017;
        • Esteller M.
        • Hamilton S.R.
        • Burger P.C.
        • Baylin S.B.
        • Herman J.G.
        Inactivation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia.
        Cancer Res. 1999;
        • Garner T.B.
        • Del Curling O.
        • Kelly D.L.
        • Laster D.W.
        The natural history of intracranial venous angiomas.
        J Neurosurg. 1991;
        • McLaughlin M.R.
        • Kondziolka D.
        • Flickinger J.C.
        • Lunsford S.
        • Lunsford L.D.
        The prospective natural history of cerebral venous malformations.
        Neurosurgery. 1998;
        • Diestro J.D.B.
        • Spears J.
        • Marotta T.R.
        Developmental Venous Anomaly Inside a Glioblastoma. 2020;
        • Gallia G.L.
        • Rand V.
        • Siu I.M.
        • et al.
        PIK3CA gene mutations in pediatric and adult glioblastoma multiforme.
        Mol Cancer Res. 2006;
        • Limaye N.
        • Kangas J.
        • Mendola A.
        • et al.
        Somatic activating PIK3CA mutations cause venous malformation.
        Am J Hum Genet. 2015;
        • Brinjikji W.
        • Hilditch C.A.
        • Tsang A.C.
        • Nicholson P.J.
        • Krings T.
        • Agid R.
        Facial venous malformations are associated with cerebral developmental venous anomalies.
        Am J Neuroradiol. 2018;
        • Roux A.
        • Vikkula M.
        • Pallud J.
        Letter: is developmental venous anomaly an imaging biomarker of PIK3CA mutated gliomas?.
        Neurosurgery. 2020;