Highlights
- •Cytokines mediate the progression and recovery of GBS.
- •CSF cytokines of Th17 pathway are associated with GBS.
- •CSF cytokines of Th17 pathway influence symptom duration in GBS.
Abstract
Data indexing the contribution of various immuno-inflammatory components in the cerebrospinal
fluid (CSF) towards the pathophysiology of Guillain Barré Syndrome (GBS) are limited.
Th17 pathway plays crucial role in many immune mediated disorders of the nervous system.
This study was aimed at exploring the role of Th17 pathway related cytokines in the
CSF of patients with GBS. Levels of multiple key cytokines of Th17 pathway in CSF
of patients with GBS (N = 37) and controls (N = 37) were examined in this prospective
study using Bio-plex Pro Human Th17 cytokine assays in a Multiplex Suspension Array
platform. The findings were correlated with clinical features and electrophysiological
subtypes. Three key cytokines of Th17 pathway (IL-6, IL-17A and IL-22) were significantly
elevated in CSF of patients with GBS as compared to controls. There was a positive
correlation between the levels of IL-6 and IL-17A as well as between the levels of
IL-17A and IL-22 in the CSF of patients with GBS. The CSF levels of IL-6 and IL-22
were negatively correlated with the duration of symptoms of GBS. None of the studied
cytokines correlated with functional disability scores at admission to hospital or
with the electrophysiological subtypes. Identification of Th17 pathway signatures
in CSF sheds more insights into the pathogenic role of Th17 cells in GBS. These findings
complement the contemporary knowledge and tender further support towards the involvement
of Th17 pathway in GBS.
Keywords
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Article info
Publication history
Published online: March 23, 2020
Accepted:
March 8,
2020
Received:
January 2,
2020
Identification
Copyright
© 2020 Elsevier Ltd. All rights reserved.
