Highlights
- •Patients with moyamoya disease have renal artery lesions and renovascular hypertension.
- •Postoperative complications are more likely to occur in moyamoya disease patients with hypertension.
- •Stages of hypertension and whether or not taking antihypertensive drugs are associated with clinical outcomes.
Abstract
Objective
Our study aimed to compare the disparity of patients with moyamoya disease (MMD) between
hypertension group and non-hypertension group. And we attempt to explore the risk
factors for MMD with hypertension.
Methods
We retrospectively analyze 542 adult patients with moyamoya disease admitted to our
hospital from 2009 to 2016. In view of inclusion criteria, we divided patients with
moyamoya disease into two groups (hypertension group and non-hypertension group) and
summarized their clinical characteristics. Furthermore, we explore the risk factors
for unfavorable outcomes in hypertension group.
Results
Of 542 adult patients with moyamoya disease, we identified 156 patients (28.8%) with
hypertension and 386 patients (71.2%) without hypertension. During follow-up, we hold
the views that the prognosis of non-hypertension group was obviously better than hypertension
group (P = 0.005) and the complications were prone to occurring to patients with hypertension
(P = 0.037). In the multivariate analysis, severe hypertension (OR, 2.746; 95% CI,
1.096–6.822; P = 0.031) and no anti-hypertensive medication (OR, 0.342; 95% CI, 0.131–1.895;
P = 0.029) were the independent predictors for postoperative unfavorable outcomes.
The common surgical modalities of moyamoya disease (direct and indirect bypass) had
no significant difference in future unfavorable outcomes prevention in adult MMD patients
with hypertension.
Conclusions
We suggested severe hypertension and no anti-hypertensive medication as the independent
risk factors for unfavorable clinical outcomes in adult MMD with hypertension.
Keywords
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Article info
Publication history
Published online: April 02, 2020
Accepted:
December 1,
2019
Received:
August 31,
2019
Identification
Copyright
© 2019 Published by Elsevier Ltd.
