Highlights
- •This case illustrates rapid improvement in PML following bacterial pyelonephritis.
- •Clinical recovery was accompanied by marked reduction in PCR titer of JCV in CSF.
- •Increased urinary viral load associated with pyelonephritis at the site of latent JCV.
- •The immune response to JCV might be triggered by bacterial pyelonephritis.
Abstract
Progressive multifocal leukoencephalopathy (PML) is caused by John Cunningham (JC)
virus in immunocompromized patients such as those with human immunodeficiency virus
(HIV) infection, hematological malignancy, autoimmune disorder, and immunodeficiency
disorder as well as those undergoing chemotherapy or immunosuppressive therapy. No
effective treatments have been established for PML, which commonly causes severe neurological
sequelae. We describe the first case of PML in a patient without HIV infection who
exhibited remarkable improvement following acute pyelonephritis with Escherichia coli bacteremia.
Keywords
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References
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Article info
Publication history
Published online: January 03, 2019
Accepted:
December 23,
2018
Received:
November 10,
2018
Identification
Copyright
© 2018 Elsevier Ltd. All rights reserved.
