Abstract
Intradural Extramedullary Spinal Melanocytoma (IESM) is an extremely uncommon tumour
arising from the spinal leptomeninges; both from a gross pathology and microscopic
point of view it can mimick its malignant counterpart, the Melanoma. Such tumours
are usually solitary, with a lower proliferating rate and without obvious SC invasion.
Their common differential diagnoses include Spinal Schwannoma and Spinal Meningiomas
since they share a significant amount of radiological similarities. It is a relatively
benign condition which is, to date, with no more than 24 previously reported cases,
yet widely unexplored and poorly understood. We report the detailed clinical history
of a 60 years old individual suffering from IESM and, by means of a thorough Literature
review, the most relevant features concerning the epidemiological issues, the clinical
course, the radiological appearance, the surgical results and the typical gross and
microscopic pathology of a cohort of previously reported cases of IESM are extensively
discussed and systematically investigated through statistical analyses in order to
add to the relevant Literature a dedicated work concerning this rare and enigmatic
condition.
Abbreviations:
MM (meningeal melanocytoma), CNS (central nervous system), IESM (intradural extramedullary spinal melanocytomas), GTR (gross total resection), RMC scale (royal medical council scale), TcMEPs (transcranial motor evoked potentials), SSEPs (somatosensory evoked potentials), EMG (electromiography), MRI (magnetic resonance imaging), EMA (epithelial membrane antigen), HMB-45 (human black melanoma 45 protein), WHO (World Health Organization)Keywords
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Article info
Publication history
Published online: December 20, 2018
Accepted:
December 11,
2018
Received:
October 30,
2018
Identification
Copyright
© 2018 Elsevier Ltd. All rights reserved.
