Highlights
- •Primary intraspinal lymphoma is a rare differential diagnosis in patients with paraplegia.
- •Clinical presentation and MR-imaging mimics differential diagnosis such as myelitis.
- •Spinal biopsy can confirm the diagnosis and should thus be performed early.
- •Early treatment is prognostically relevant for neurological outcome and survival.
Abstract
We present the unique case of an 67-year-old female patient with primary intraspinal
B-cell non-Hodgkin’s lymphoma without cerebral manifestation mimicking myelitis in
clinical presentation and neuroradiological diagnostic. It illustrates the broad spectrum
of differential diagnoses for paraplegia and the importance of rapid interdisciplinary
diagnostic work-up since the neurologic status after treatment mainly depends on the
delay of treatment. Review of existing literature suggests combined radio- and chemotherapy
as well as high-dose intravenous methotrexate or rituximab. The rising incidence of
spinal lymphomas especially in patients with acquired immunodeficiency underlines
the importance of fast diagnosis and initiation of treatment of this rare entity.
Keywords
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Article info
Publication history
Published online: November 21, 2018
Accepted:
November 12,
2018
Received:
October 15,
2018
Identification
Copyright
© 2018 Elsevier Ltd. All rights reserved.
