Highlights
- •Abnormal RBC indices increase risk of ATE and VTE.
- •Low MCV, MCH and high RDW levels were risk factors of AIS in this population.
- •Abnormal RBC indices may contribute to the disturbance of endothelial system.
Abstract
A high red cell distribution width (RDW) and low hemoglobin level increase the risk
of arterial ischemic stroke (AIS), mostly in adults. The mechanisms related to AIS
remain unknown. A total of 233 subjects (90 patients and 143 healthy controls [HC])
were enrolled. The mean(SD) age in patients and HC was 9.5(3.8) and 11.4(1.8) years,
respectively. We found increased odds ratios (ORs) for large vessel and small vessel
subtypes in patients without underlying diseases with a mean corpuscular volume (MCV)
<80 fL (OR: 5.4, 95%CI 1.8–16.3 and 2.8, 95%CI 1.2–7.2), mean corpuscular hemoglobin
levels <27 pg (OR: 2.9, 95%CI 1.0–6.7 and 2.6, 95%CI 1.0–6.7), and RDW >15% (OR: 5.5,
95%CI 1.3–24.5 and 2.7, 95%CI 1.0–7.3). RBC indices showed significant correlations
with TM levels. Therefore, low MCV and MCH levels, and a high RDW were risk factors
for AIS and associated with TM levels in this population.
Keywords
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Article info
Publication history
Published online: December 19, 2018
Accepted:
December 11,
2018
Received:
October 3,
2018
Identification
Copyright
© 2018 Elsevier Ltd. All rights reserved.
