Highlights
- •We evaluate structural volumes and connectivity in patients with cluster headache.
- •The volumes of the left caudal anterior cingulate and postcentral gyrus are decreased.
- •Significant hub re-organizations are found in the measures of local structural connectivity.
- •These alterations are implicated in the pathogenesis of cluster headache.
Abstract
We evaluated structural volumes and connectivity using graph theoretical analysis
in patients with cluster headache. Ten patients with episodic cluster headache were
recruited, who had a normal brain MRI on visual inspection. We also enrolled a control
group of 20 healthy volunteers. All of the participants underwent 3-D volumetric T1-weighted
imaging. We obtained the structural volumes using FreeSurfer image analysis and performed
structural global and local connectivity analysis using BRAPH. The volumes of the
left caudal anterior cingulate and postcentral gyrus were decreased in the patients
with cluster headache compared to healthy individuals. In addition, in the measures
of local structural connectivity, there was significant hub re-organization in the
patients with cluster headache; the strength of the right frontopolar, left pericalcarine,
and left posterior cingulate gyrus, the betweenness centrality of the right precentral
and left pericalcarine gyrus, and the closeness centrality of the left pericalcarine
and left posterior cingulate gyrus were decreased. Whereas the betweenness centrality
of the right rostral middle frontal and left inferior temporal gyrus were increased
in the patients with cluster headache. However, the measures of global structural
connectivity were not different between the patients with cluster headache and healthy
individuals. We demonstrate that the structural volumes and connectivity in patients
with cluster headache are significantly different from those in healthy controls,
especially revealing hub re-organization. These alterations are implicated in the
pathogenesis of cluster headache and suggest that cluster headache is a network disease.
Keywords
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Article info
Publication history
Published online: January 14, 2019
Accepted:
January 3,
2019
Received:
September 4,
2018
Identification
Copyright
© 2019 Elsevier Ltd. All rights reserved.
