- •Neuregulin 1 (NRG1) is a peliotropic growth factor, important in neuronal development and functions.
- •Altered function of NRG1 and its receptor ErbB4 may contribute the pathogenesis of Schizophrenia.
- •Shizophrenia and autism may have common pathogenic mechanisms.
- •This study found that peripheric NRG1 levels is increased in ASD patients.
- •NRG1 may play a role in ASD pathogenesis.
Though schizophrenia and autism spectrum disorders (ASD) are separate diseases, they have some common clinical manifestations and common pathogenic mechanisms. Numerous genes are associated with these conditions. Among these genes, Neuregulin-1 forms a risk for schizophrenia and some studies have shown polymorphism of this gene accompanies schizophrenia. NRG1 has a wide variety of functions, including neuronal migration, axon guidance, synaptic transmission, oligodendroglial maturation, and neurite outgrowth. To date, NRG1 levels have not been researched in ASD patients and considering the neurodevelopmental effects of NRG1, this study aimed to research the peripheral NRG1 levels in ASD patients. The study compared 32 ASD patients and 32 healthy controls. Serum NRG-1 levels were measured with ELISA. In ASD patients (mean ± SD, 10.80 ± 4.78 ng/ml), the NRG1 levels were found to be statistically significantly high compared to the health control group (mean ± SD, 6.92 ± 4.91 ng/ml) (p = 0.004). According to the results we obtained, NRG1 was shown to play a possible role in ASD pathogenesis. There is a need for advanced studies on the possible role of NRG1 in ASD patients. This study is significant as it is the first study to measure peripheral NRG1 in ASD patients.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Journal of Clinical Neuroscience
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- The genetic architecture of schizophrenia, bipolar disorder, obsessive-compulsive disorder and autism spectrum disorder.Mol Cell Neurosci. 2018; 88: 300-307
- Genetic insights into the neurodevelopmental origins of schizophrenia.Nat Rev Neurosci. 2017; 18: 727
- A review of endophenotypes in schizophrenia and autism: The next phase for understanding genetic etiologies.Am J Med Genet Part C: Semin Med Genet. 2017; 175: 354-361
- Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology.Biol Psychiatry. 2006; 60: 132-140
- Neuregulin 1 and schizophrenia.Ann Med. 2004; 36: 62-71
- Association study of neuregulin 1 gene with schizophrenia.Mol Psychiatry. 2003; 8: 706
- Association of the DISC1 and NRG1 genetic polymorphisms with schizophrenia in a Chinese population.Gene. 2016; 590: 293-297
- Neuregulin 1 and susceptibility to schizophrenia.Am J Hum Genet. 2002; 71: 877-892
- Association between Neuregulin-1 gene variant (rs2439272) and schizophrenia and its negative symptoms in an Iranian population.Iran J Psychiatry. 2016; 11: 147
- Explorative study on the expression of neuregulin-1 gene in peripheral blood of schizophrenia.Neurosci Lett. 2008; 438: 1-5
- Decreased plasma levels of neureglin-1 in drug naïve patients and chronic patients with schizophrenia.Neurosci Lett. 2015; 606: 220-224
- Measurement and comparison of serum neuregulin 1 immunoreactivity in control subjects and patients with schizophrenia: an influence of its genetic polymorphism.J Neural Transm. 2010; 117: 887-895
- Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases.Neuron. 2014; 83: 27-49
- Neuregulin 1-erbB signaling and the molecular/cellular basis of schizophrenia.Nat Neurosci. 2004; 7: 575
- Neuregulin 1 in neural development, synaptic plasticity and schizophrenia.Nat Rev Neurosci. 2008; 9: 437
- Genetic association analyses of neuregulin 1 gene polymorphism with endopheontype for sociality of Korean autism spectrum disorders family.Psychiatry Res. 2015; 227: 366-368
- Transient overexposure neuregulin 3 during early postnatal development impacts selective behaviors in adulthood.PLoS One. 2014; 9e104172
- Neuregulin-1 signals from the periphery regulate AMPA receptor sensitivity and expressionin GABAergic interneurons in developing neocortex.J Neurosci. 2011; 31: 5699-5709
- Transient exposure of neonatal mice to neuregulin-1 results in hyperdopaminergic states in adulthood: implication in neurodevelopmental hypothesis ofr schizophrenia.Mol Psychiatry. 2011; 16: 307
- Behavioral, neurophisiological, and synaptic impairment in a transgenic neuregulin 1 (NRG1-IV) murine schizophrenia model.J Neurosci. 2016; 36: 4859-4875
Published online: August 24, 2018
Accepted: August 13, 2018
Received: April 11, 2018
☆Note: This study was presented as an oral presentation at 10th International Congress on Psychopharmacology & 6th International Symposium on Child and Adolescent Psychopharmacology April 25–29, 2018 in Gloria Congress Venue, Antalya, Turkey.
© 2018 Elsevier Ltd. All rights reserved.