Highlights
- •Metachronous was defined when primary tumor was diagnosed before spine metastasis.
- •The incidence rate of the metachronous group was significantly higher than that of the synchronous group.
- •Patients in the synchronous group survived significantly longer than those in the metachronous group.
- •Among combination treatment modalities, surgery combined with RT was the most common treatment.
Abstract
This nationwide study of the adult Korean population aimed to compare the survival
period between synchronous and metachronous group and to determine recent treatment
trends in newly diagnosed spine metastasis patients.
Data were extracted from the Korean Health Insurance Review and Assessment Service
database. Patients in this study were newly diagnosed with metastatic spine tumors
between July 1, 2011 and June 31, 2014. The metachronous group was defined when the
primary tumor was diagnosed prior to the diagnosis of spine metastasis, otherwise
patients were considered to be the part of the synchronous group. The survival period
was calculated from the date of first diagnosis of spine metastasis.
In a multivariate analysis, patients in the synchronous group survived significantly
longer than those in the metachronous group (P < 0.0001). Median overall survival periods were 273.6 days for the metachronous group
and 541.4 days for the synchronous group. Conventional radiation therapy (RT) was
the most common treatment modality for metastatic spine tumors, whereas surgery combined
with RT was a steadily increasing treatment modality during the study period.
Synchronous spine metastasis patients survive significantly longer than metachronous
patients. Surgery combined with RT is a recently increasing trend among spine metastasis
treatments.
Keywords
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Article info
Publication history
Published online: August 29, 2018
Accepted:
August 19,
2018
Received:
March 20,
2018
Identification
Copyright
© 2018 Elsevier Ltd. All rights reserved.
