Highlights
- •EBV associated lymphoma is a recognised complication in immunosuppressed patients.
- •Primary CNS lymphoma is rare, particularly involving the posterior fossa.
- •A myasthenia gravis patient treated with azathioprine developed a rare lymphoma.
Abstract
We report a case of a 40 year old female who presented with a three month history
of headaches with a background of Myasthenia Gravis (MG), treated with azathioprine.
MRI brain demonstrated a rim-enhancing lesion in the left posterior fossa. CT scan
of the chest abdomen and pelvis revealed no other lesion. The patient was taken for
resection of the lesion via left retrosigmoid approach. Histologically the neoplasm
was a large B-cell lymphoma, Epstein-Barr virus (EBV) positive, with clonality confirmed
by IGH gene rearrangement studies. To the best of our knowledge this is the first
case of primary central nervous system (CNS) EBV-positive diffuse large B-cell lymphoma
of the posterior fossa in a patient with MG treated with azathioprine.
Keywords
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Article info
Publication history
Published online: August 23, 2018
Accepted:
August 12,
2018
Received:
January 12,
2018
Identification
Copyright
© 2018 Elsevier Ltd. All rights reserved.
