Highlights
- •Patients who had cellular or papillary subtype would have a shorter estimated value of progression-free time.
- •Patients who were treated with adjuvant therapy had a higher risk of progression.
- •Giant cell ependymoma patients would have a higher risk of fatality.
Abstract
This study evaluated survival outcomes of patients with intramedullary Grade II ependymomas
and identify prognostic factors. Electronic searches of PubMed, EMBASE, OVID, the
Cochrane Central Register of Controlled Trials were performed to identify trials according
to the Cochrane Collaboration guidelines. The objects were intramedullary Grade II
ependymoma according to 2007 WHO classification. Kaplan–Meier survival analysis with
log-rank test was used to analyze progressive free survival (PFS) and overall survival
(OS). Cox proportional hazard model was utilized for multivariate analysis with hazard
ratio (HR) and 95% confidence interval (CI) calculated. P values <0.05 were considered statistically significant. A total of 28 studies including
138 cases of intramedullary Grade II ependymomas were retrieved. Patients who were
classified as cellular ependymomas or papillary ependymomas had higher risks of progression
than those who possessed typical Grade II ependymomas. Patients who were treated with
adjuvant therapy had a higher risk of progression than those without adjuvant therapy.
OS of patients with giant cell ependymoma was significantly shorter than those with
typical Grade II ependymoma. Patients who had cellular or papillary subtype, adjuvant
therapy would have a shorter estimated value of progression-free time and a higher
risk of progression than typical Grade II ependymomas. Giant cell ependymoma patients
would have a higher risk of fatality than those with typical Grade II ependymomas.
Definite pathology type and appropriate treatments were foundations of intramedullary
Grade II ependymomas’ managements.
Keywords
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Article info
Publication history
Published online: August 23, 2018
Accepted:
August 8,
2018
Received:
December 17,
2017
Identification
Copyright
© 2018 Elsevier Ltd. All rights reserved.
