Highlights
- •Patients with Parkinson’s disease have an increased risk of perioperative morbidity.
- •Awareness of anaesthetic risks and medication requirements may improve outcomes.
- •There is little evidence linking anaesthetic exposure to development of the disease.
Abstract
Parkinson’s disease is a common neurodegenerative disorder in the elderly which when
present has a significant influence on surgical management. These patients necessitate
additional perioperative and anaesthetic considerations across disease specific domains
as well as in relation to the respiratory and cardiovascular systems. This brief review
focuses on the factors which contribute to perioperative morbidity, including the
use of medications that may exacerbate symptoms or adversely interact with treatments
for Parkinson’s disease. Recommended dosing practices to reduce complications during
hospitalisation are covered. In addition, recent concerns regarding anaesthetic exposure
in early childhood as a risk factor for the development of Parkinson’s disease are
discussed in light of data from animal models of anaesthetic neurotoxicity and epidemiological
studies.
Keywords
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Article info
Publication history
Published online: November 10, 2017
Accepted:
October 23,
2017
Received:
June 23,
2017
Identification
Copyright
© 2017 Elsevier Ltd. All rights reserved.
