- •Cryptococcosis is a potentially fatal fungal infection that has a good prognosis if it is recognized and treated early.
- •Typically, cryptococcosis is associated with the immunocompromised patient. However, there are increasing reports that the immunocompetent population can be infected by this yeast as well.
- •This is the first reported case of infection by Cryptoccoccus spp. in an immunocompetent host, successfully mimicking a diagnosis of primary lung carcinoma with brain metastases. This clinical scenario demonstrates that disseminated cryptococcosis can successfully mimic other more common disease states.
Cryptococcosis is a fungal infection caused by Cryptococcus spp. that enters the body via inhalation. This ubiquitous yeast has gained notoriety as an opportunistic pathogen in the immunosuppressed population. The authors report a case of a previously-well adult male presented with left-sided weakness. Imaging demonstrated a pulmonary mass and 2 contrast-enhancing intracranial lesions—all features suggestive of a primary lung carcinoma with brain metastases. However, further investigations confirmed disseminated cryptococcosis, without evidence of malignancy. The patient was successfully treated with a course of antifungals. To the authors’ knowledge, this is the first reported case of dissemintated cryptococcosis in an immunocompetent adult male, simulating as primary lung carcinoma with brain metastases.
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- Fungal central nervous system infections: prevalence and diagnosis.Exp Rev Anti-infective Therap. 2014; 12: 265-273
- Characterization of a murine monoclonal antibody to Cryptococcus neoformans polysaccharide that is a candidate for human therapeutic studies.Antimicrob Agents Chemother. 1998; 42: 1437-1446
- Primary cutaneous cryptococcosis due to Cryptococcus gattii in Singapore.Singapore Med J. 2011; 52: e160-e162
- Magnetic resonance spectroscopy findings of pyogenic, tuberculous, and Cryptococcus intracranial abscesses.Neurochem Res. 2012; 37: 233-237
- The role of proton magnetic resonance spectroscopy in the diagnosis and categorization of cerebral abscesses.Neurosurg Focus. 2008; 24: E7
- Brain lesions in patients with AIDS: H-1 MR spectroscopy.Radiology. 1995; 197: 525-531
Published online: October 18, 2016
Accepted: September 26, 2016
Received: July 13, 2016
© 2016 Elsevier Ltd. All rights reserved.