Abstract
We retrospectively studied 105 patients with a focal cortical dysplasia (FCD) diagnosed
on pathological examination, and investigated the long term postoperative seizure
outcomes, different clinical characteristics of the three FCD subtypes, particularly
type I and II, and surgical outcomes for each group. FCD is a common cause of drug-resistant
epilepsy, which is divided into three different subtypes according to its involvement
at different stages of brain development. Each of these groups may have different
characteristics and may even have different surgical outcomes. After treatment, 55%
of patients were completely seizure-free, with two significant predictive variables
for poorer outcomes: focal MRI findings and electrode implantation. FCD type I had
relatively poor surgical outcomes compared to FCD type II and type IIIa. Compared
with FCD type I, type II, particularly IIb, had a higher frequency of seizure attacks,
predominantly located in the extratemporal lobes, and was more readily detected and
diagnosed via focal lesions on MRI and localized electroencephalogram abnormalities.
FCD type II patients seem to show better surgical outcomes than FCD type I, but the
difference was not significant. Larger cohort studies are needed for further evaluation
of the seizure outcomes of different FCD subtypes.
Keywords
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Article info
Publication history
Published online: July 16, 2015
Accepted:
April 11,
2015
Received:
October 13,
2014
Identification
Copyright
© 2015 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
