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Association between sepsis and dementia

  • Li-Ting Kao
    Affiliations
    Graduate Institute of Life Science, National Defense Medical Center, Taipei, Taiwan

    Sleep Research Center, Taipei Medical University Hospital, Taipei, Taiwan
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  • Jau-Jiuan Sheu
    Affiliations
    Department of Neurology, Taipei Medical University Hospital, Taipei, Taiwan

    Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
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  • Author Footnotes
    1 Equal contribution to this study.
    Herng-Ching Lin
    Footnotes
    1 Equal contribution to this study.
    Affiliations
    School of Health Care Administration, Taipei Medical University, 250 Wu-Hsin Street, Taipei 110, Taiwan

    Sleep Research Center, Taipei Medical University Hospital, Taipei, Taiwan
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  • Ming-Chieh Tsai
    Affiliations
    School of Health Care Administration, Taipei Medical University, 250 Wu-Hsin Street, Taipei 110, Taiwan

    Division of Gastroenterology, Department of Internal Medicine, General Cathay Hospital, Taipei, Taiwan
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  • Author Footnotes
    1 Equal contribution to this study.
    Shiu-Dong Chung
    Correspondence
    Corresponding author at: Division of Urology, Department of Surgery, Far Eastern Memorial Hospital, School of Medicine, Fu-Jen Catholic University,New Taipei, Taiwan.
    Footnotes
    1 Equal contribution to this study.
    Affiliations
    Sleep Research Center, Taipei Medical University Hospital, Taipei, Taiwan

    Division of Urology, Department of Surgery, Far Eastern Memorial Hospital, New Taipei City, Taiwan
    Search for articles by this author
  • Author Footnotes
    1 Equal contribution to this study.
Published:April 04, 2015DOI:https://doi.org/10.1016/j.jocn.2015.02.035

      Abstract

      In this study, we explored the association between sepsis and dementia using a population-based dataset in Taiwan and a case-control design. The relationship between severe systemic infections and dementia is still unclear. Data for this case-control study were taken from the Taiwan Longitudinal Health Insurance Database 2000. This study included 5955 patients with dementia and 5955 sex and age-matched healthy controls. We performed conditional logistic regressions to examine the association of dementia with previously diagnosed sepsis. We found that 168 (1.41%) of the sampled people had been hospitalized for treatment of sepsis before the index date, 122 patients (2.05%) and 46 controls (0.77%; p < 0.001). The conditional logistic regression indicated that patients with dementia were more likely to have been previously diagnosed with sepsis than controls after adjusting for monthly income, urbanization level, hyperlipidemia, and diabetes (odds ratio [OR] 2.60; 95% confidence interval [CI] 1.84–3.66). We also found that dementia was associated with prior sepsis regardless of sex (males: adjusted OR 3.17; 95% CI 1.76–5.68; females: adjusted OR 2.27; 95% CI 1.48–3.47). We concluded that patients with dementia had a higher odds of previous sepsis compared to the control group.

      Keywords

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