Abstract
In this study, we explored the association between sepsis and dementia using a population-based
dataset in Taiwan and a case-control design. The relationship between severe systemic
infections and dementia is still unclear. Data for this case-control study were taken
from the Taiwan Longitudinal Health Insurance Database 2000. This study included 5955
patients with dementia and 5955 sex and age-matched healthy controls. We performed
conditional logistic regressions to examine the association of dementia with previously
diagnosed sepsis. We found that 168 (1.41%) of the sampled people had been hospitalized
for treatment of sepsis before the index date, 122 patients (2.05%) and 46 controls
(0.77%; p < 0.001). The conditional logistic regression indicated that patients with dementia
were more likely to have been previously diagnosed with sepsis than controls after
adjusting for monthly income, urbanization level, hyperlipidemia, and diabetes (odds
ratio [OR] 2.60; 95% confidence interval [CI] 1.84–3.66). We also found that dementia
was associated with prior sepsis regardless of sex (males: adjusted OR 3.17; 95% CI
1.76–5.68; females: adjusted OR 2.27; 95% CI 1.48–3.47). We concluded that patients
with dementia had a higher odds of previous sepsis compared to the control group.
Keywords
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Article info
Publication history
Published online: April 04, 2015
Accepted:
February 25,
2015
Received:
March 7,
2014
Identification
Copyright
© 2015 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
