Abstract
Spinal nerve root metastasis of renal cell carcinoma is a rare occurrence. In addition
to treatment of the primary lesion, surgical resection of the nerve root metastasis,
occasionally with sacrifice of the involved nerve, is the accepted standard of treatment.
Resection often resolves presenting motor and pain symptoms due to relief of neural
compression. We describe two patients with nerve root metastasis of renal cell carcinoma
and their management. While locally advanced and metastatic renal cell carcinoma has
been shown to be chemo- and radio-resistant, immunotherapy is a promising treatment.
Given the high prevalence of systemic disease in patients with intradural metastases,
systemic (and possibly intracranial) imaging can be used to identify other potential
areas of disease.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Clinical NeuroscienceAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Intradural spinal metastasis of renal cell cancer. Report of a case and review of 26 published cases.Acta Neurochir (Wien). 2009; 151 ([discussion 821]): 815-821
- Renal cell carcinoma and intradural spinal metastasis with cauda equina infiltration: case report.Spine (Phila Pa 1976). 2005; 30: 161-163
- Intramedullary spinal cord metastases from a hypernephroma 11 years following the diagnosis and treatment of the primary lesion.Br J Neurosurg. 2000; 14: 474-476
- Intramedullary spinal cord metastasis (ISCM) in renal cell carcinoma: a series of six cases.Ann Oncol. 2001; 12: 1173-1177
- Intramedullary spinal cord metastasis: a rare and devastating complication of cancer–two case reports.Neurol Med Chir (Tokyo). 2003; 43: 612-615
- Renal cell carcinoma: a rare source of cauda equina metastasis. Case report.J Neurosurg. 1999; 90: 129-132
- Intramedullary spinal cord metastasis as a first manifestation of a renal cell carcinoma: report of a case and review of the literature.Clin Neurol Neurosurg. 2000; 102: 249-254
- Intradural spinal metastasis to the cauda equina in renal cell carcinoma: a case report and review of the literature.Spine (Phila Pa 1976). 2009; 34: E892-E895
- A rare case of metastatic renal cell carcinoma resembling a nerve sheath tumor of the cauda equina.J Clin Neurosci. 2004; 11: 530-532
- Intramedullary spinal cord metastasis from renal cell carcinoma: detection by positron emission tomography.Clin Nucl Med. 2001; 26: 837-839
- Solitary intradural extramedullary metastasis of renal cell carcinoma to the conus medullaris.Kaohsiung J Med Sci. 2011; 27: 45-48
- Endoneural metastasis of the sciatic nerve disclosing the relapse of a renal carcinoma, four years after its surgical treatment.Joint Bone Spine. 2006; 73: 760-762
- An uncommon cause of sciatica.J Coll Physicians Surg Pak. 2009; 19: 127-129
- Metastases to hemangioblastomas in von Hippel-Lindau disease.J Neurosurg. 2006; 105: 256-263
- Metastatic renal cell carcinoma to hemangioblastoma in von Hippel-Lindau disease.Arch Pathol Lab Med. 2007; 131: 641-645
- Metastasis of renal cell carcinoma to central nervous system hemangioblastoma in two patients with von Hippel-Lindau disease.Pathol Int. 2001; 51: 948-953
- Spinal hemangioblastoma containing metastatic renal cell carcinoma in von Hippel-Lindau disease. Case report and review of the literature.J Neurosurg Spine. 2005; 3: 495-500
- Metastasis of renal cell carcinoma to haemangioblastoma of the spinal cord in von Hippel-Lindau disease: case report and review of the literature.Pathology. 2003; 35: 224-227
- Metastasis of renal cell carcinoma to a haemangioblastoma of the medulla oblongata in von Hippel-Lindau syndrome.J Clin Neurosci. 2010; 17: 1213-1215
- A 41-year-old woman with von Hippel-Lindau and a cerebellar lesion.Brain Pathol. 2010; 20: 511-514
- Metastasis of clear-cell renal carcinoma to cerebellar hemangioblastoma in von Hippel Lindau disease: rare or not investigated?.Acta Neurochir (Wien). 2001; 143: 1059-1063
- Metastasis of renal carcinoma to a cerebellar hemangioblastoma in a patient with von Hippel Lindau disease: a case report.Br J Neurosurg. 1999; 13: 413-416
- Metastasis of a renal carcinoma to a cerebellar haemangioblastoma in a case of von Hippel-Lindau disease.Neurosurg Rev. 1992; 15: 231-234
- Renal cell carcinoma metastases. Review of unusual clinical metastases, metastatic modes and patterns and comparison between clinical and autopsy metastatic series.Scand J Urol Nephrol. 1996; 30: 165-172
- The function of the vertebral veins and their role in the spread of metastases.Ann Surg. 1940; 112: 138-149
- The cerebrospinal venous system: anatomy, physiology, and clinical implications.MedGenMed. 2006; 8: 53
- Renal-cell carcinoma.N Engl J Med. 1996; 335: 865-875
- Surgical treatment of metastases from renal cell carcinoma.Arch Ital Urol Androl. 2005; 77: 125-128
- Vascular endothelial growth factor (VEGF) receptor antibody bevacizumab (avastin) induces regression of renal cell carcinoma in an adolescent resulting in residual tumorectomy.Pediatr Blood Cancer. 2008; 50: 903-904
- Recent advances in molecular targeted therapy for metastatic renal cell carcinoma.Int J Urol. 2009; 16: 444-448
- Sorafenib in advanced clear-cell renal-cell carcinoma.N Engl J Med. 2007; 356: 125-134
- Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial.Lancet. 2007; 370: 2103-2111
- Sunitinib versus interferon alfa in metastatic renal-cell carcinoma.N Engl J Med. 2007; 356: 115-124
- Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study.Lancet Oncol. 2007; 8: 975-984
- Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma.N Engl J Med. 2007; 356: 2271-2281
- Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial.Lancet. 2008; 372: 449-456
- Unusual metastasis to the cauda equina from renal cell carcinoma.Spine (Phila Pa 1976). 2003; 28: E114-E117
Article info
Publication history
Accepted:
February 19,
2013
Received:
February 11,
2013
Identification
Copyright
© 2013 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.