Abstract
Infliximab, a tumor necrosis factor-alpha antagonist, is used to treat many inflammatory
diseases. Various forms of demyelinating neuropathies have been reported as neurological
complications associated with infliximab use. There have been few reports of pure
sensory neuropathy associated with infliximab. We report the clinical, electrophysiological,
and pathological findings of a patient with subacute sensory polyradiculopathy 1 month after infliximab therapy for psoriasis vulgaris. Immune-mediated pathogenesis
was suggested by positive anti-ganglioside antibodies and rapid response to intravenous
immunoglobulin. This is the first reported case of sensory polyradiculopathy with
positive anti-ganglioside antibodies following infliximab therapy. Our findings suggest
the clinical importance of immunological investigations and treatment in demyelinating
neuropathies following infliximab therapy.
Keywords
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Article info
Publication history
Accepted:
December 10,
2012
Received:
August 12,
2012
Identification
Copyright
© 2013 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
