Abstract
Pleomorphic xanthoastrocytoma (PXA) is a rare tumor with good prognosis after surgery.
Few cases of anaplastic PXA (either de novo or secondary to transformation of a recurrent low grade PXA) have been reported.
Moreover, primary anaplastic PXA with dissemination at diagnosis has been described
only in two patients, to our knowledge. We report the first case of primary multicentric
anaplastic PXA and discuss its atypical features and the pertinent literature.
Keywords
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References
- Analysis of p53 mutation and expression in pleomorphic xanthoastrocytoma.Neurogenetics. 2001; 3: 159-162
- A case of anaplastic pleomorphic xanthoastrocytoma presenting with tumor bleeding and cerebrospinal fluid dissemination.Brain Tumor Pathol. 2006; 23: 55-63
- Malignant progression in pleomorphic xanthoastrocytoma: personal experience and review of the literature.J Neurol Sci. 2007; 252: 144-153
- Cerebral anaplastic pleomorphic xanthoastrocytoma with meningeal dissemination at first presentation.Childs Nerv Syst. 2004; 20: 119-122
- Primary anaplastic pleomorphic xanthoastrocytoma with widespread neuroaxis dissemination at diagnosis–a pediatric case report and review of the literature.J Neurooncol. 2009; 94: 431-437
- Anaplastic pleomorphic xanthoastrocytoma.Childs Nerv Syst. 1997; 13: 50-56
- Pleomorphic xanthoastrocytoma: what do we really know about it?.Cancer. 1999; 85: 2033-2045
- Pleomorphic xanthoastrocytoma: a comparative pathological study between conventional and anaplastic types.Histopathology. 2008; 52: 183-193
- Epithelial properties of pleomorphic xanthoastrocytoma determined in ultrastructural and immunohistochemical studies.Acta Neuropathol. 1987; 74: 142-150
- Pleomorphic xanthoastrocytoma: clinical, imaging and pathological features of four cases.Clin Neurol Neurosurg. 1997; 99: 40-45
- Pleomorphic xanthoastrocytoma: favorable outcome after complete surgical resection.Neuro Oncol. 2001; 3: 184-192
- Pediatric cerebellar pleomorphic xanthoastrocytoma with anaplastic features: a case of long-term survival after multimodality therapy.Childs Nerv Syst. 2006; 22: 609-613
- A 28-year-old man with headache, visual and aphasic disturbances.Brain Pathol. 2009; 19: 163-166
- Long-term control of disseminated pleomorphic xanthoastrocytoma with anaplastic features by means of stereotactic irradiation.Neuro Oncol. 2009; 11: 446-451
- Anaplastic pleomorphic xanthoastrocytoma with a component of anaplastic astrocytoma presenting as skull base tumor followed by downward extracranial extension. Case report.Neurol Med Chir (Tokyo). 2010; 50: 1108-1112
- Intraventricular pleomorphic xanthoastrocytoma with anaplastic features.Neuropathology. 2010; 30: 443-448
- Synchronous multicentric pleomorphic xanthoastrocytoma: case report.Neurosurgery. 2005; 57: E191
- Multicentric pleomorphic xanthoastrocytoma in a patient with neurofibromatosis type 1. Case report and review of the literature.J Neurosurg. 2005; 102: 376-381
Article info
Publication history
Accepted:
September 11,
2012
Received:
May 23,
2012
Identification
Copyright
© 2013 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.