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Case Report| Volume 20, ISSUE 11, P1610-1612, November 2013

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Late adult onset optic pathway astrocytoma

  • Author Footnotes
    1 These authors contributed equally to this work.
    Ye Liu
    Footnotes
    1 These authors contributed equally to this work.
    Affiliations
    Department of Neurology, Shanghai First People’s Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai 200080, China
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  • Author Footnotes
    1 These authors contributed equally to this work.
    Sandy Zhang-Nunes
    Footnotes
    1 These authors contributed equally to this work.
    Affiliations
    Department of Ophthalmology, Jules Stein Eye Institute, University of California, Los Angeles, CA, USA
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  • Xiaoying Zhu
    Affiliations
    Department of Neurology, Shanghai First People’s Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai 200080, China
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  • Xun Xu
    Affiliations
    Department of Ophthalmology & Shanghai Eye Research Institute, Shanghai First People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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  • Xiaodong Sun
    Affiliations
    Department of Ophthalmology & Shanghai Eye Research Institute, Shanghai First People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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  • Yuncheng Wu
    Correspondence
    Corresponding author. Tel.: +86 21 6324 0090/3171; fax: +86 21 6324 0825.
    Affiliations
    Department of Neurology, Shanghai First People’s Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai 200080, China
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  • Author Footnotes
    1 These authors contributed equally to this work.

      Abstract

      A 70-year-old man presented with left-sided eye pain, impaired vision and restricted left ocular motility, later developing progressive visual decline with development of ataxia and incontinence. Fundoscopic examination revealed significant optic nerve head edema and hemorrhage on the left eye. Neuroimaging revealed an optic pathway mass, extending from the right optic nerve to the chiasm, which enlarged on serial imaging. After surgical excision of the mass, pathology showed a grade III astrocytoma. The patient died 16 months after presentation, which is longer than previously reported for late adult onset optic pathway astrocytoma. We believe that neuroimaging and pathological studies should be performed early in such patients to allow early diagnosis and intervention.

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      References

        • Shapey J.
        • Danesh-Meyer H.V.
        • Kaye A.H.
        Diagnosis and management of optic nerve glioma.
        J Clin Neurosci. 2011; 18: 1585-1591
        • Wabbels B.
        • Demmler A.
        • Seitz J.
        • et al.
        Unilateral adult malignant optic nerve glioma.
        Graefes Arch Clin Exp Ophthalmol. 2004; 242: 741-748
        • Alshail E.
        • Rukta J.E.
        • Becker L.E.
        • et al.
        Optic chiasmatic hypothalamic glioma.
        Brain Pathol. 1997; 7: 799-806
        • Kornreich L.
        • Blaser S.
        • Schwarz M.
        • et al.
        Optic pathway glioma: correlation of imaging findings with the presence of neurofibromatosis.
        AJNR Am J Neuroradiol. 2001; 22: 1963-1969
        • Kurt G.
        • Tonge M.
        • Börcek A.O.
        • et al.
        Fractionated gamma knife radiosurgery for optic nerve tumors: a technical report.
        Turkish Neurosurgery. 2010; 20: 241-246
        • Binning M.J.
        • Liu J.K.
        • Kestle J.R.
        • et al.
        Optic pathway gliomas: a review.
        Neurosurg Focus. 2007; 23: E2
        • Spoor T.C.
        • Kennerdell J.S.
        • Martinez A.J.
        • et al.
        Malignant gliomas of the optic nerve pathways.
        Am J Ophthalmol. 1980; 89: 284-292
        • Motta M.
        • Alongi F.
        • Bolognesi A.
        • et al.
        Remission of refractory neurosarcoidosis treated with brain radiotherapy: a case report and a literature review.
        Neurologist. 2008; 14: 120-124
        • Miller N.R.
        Primary tumours of the optic nerve and its sheath.
        Eye. 2004; 18: 1026-1037