Advertisement
Case Report| Volume 17, ISSUE 10, P1347-1349, October 2010

Download started.

Ok

Intracranial presentation of teratocarcinosarcoma

      Abstract

      Teratocarcinosarcoma (TCS), an aggressive and extremely rare neoplasm, usually presents as a nasal or paranasal mass. TCS can have intracranial or dural extension from a nasal mass. We found only two instances in the literature that described this lesion as primarily manifesting as an intracranial mass while arising from a primary nasal focus. We describe a patient who had a predominantly frontal-lobe TCS without any symptoms of a primary nasal mass. The gross surgical appearance was a glistening, slimy, firm white mucoid lesion, in contrast to the friable, necrotic and tan-colored lesion usually described. We report a patient with a rare intracranial TCS, and focus on the differential diagnoses of intracranial tumors. Neuropathologists and neurosurgeons should be aware of this mode of presentation for an accurate diagnosis and a well-targeted therapeutic approach.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of Clinical Neuroscience
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Heffner D.K.
        • Hyams V.J.
        Teratocarcinosarcoma (malignant teratoma?) of the nasal cavity and paranasal sinuses. A clinicopathologic study of 20 cases.
        Cancer. 1984; 53: 2140-2154
      1. Barnes L. Everon J.W. Reichart P. WHO classification of tumors. Pathology and genetics of head and neck tumors. IARC Press, Lyon, France2005: 9-80
        • Sharma H.S.
        • Abdullah J.M.
        • Othman N.H.
        Pathology in focus. Teratocarcinosarcoma of the nasal cavity and ethmoid.
        J Laryngol Otol. 1998; 112: 682-686
        • Wellman M.
        • Kerr P.D.
        • Battistuzzi S.
        • et al.
        Paranasal sinus teratocarcinosarcoma with intradural extension.
        J Otolaryngol. 2002; 31: 173-176
        • Lim C.C.T.
        • Thiagarajan A.
        • Sim C.S.
        • et al.
        Craniospinal dissemination in teratocarcinosarcoma.
        J Neurosurg. 2008; 109: 321-324
        • Terasaka S.
        • Medary M.B.
        • Whiting D.M.
        • et al.
        Prolonged survival in a patient with sinonasal teratocarcinosarcoma with cranial extension. Case report.
        J Neurosurg. 1998; 88: 753-756
        • Pai S.A.
        • Naresh K.N.
        • Masih K.
        • et al.
        Teratocarcinosarcoma of the paranasal sinuses: a clinicopathologic and immunohistochemical study.
        Hum Pathol. 1998; 29: 718-722
        • Rosenblum M.
        • Bilbao J.M.
        • Ang L.-C.
        Neuromuscular system.
        in: Rosai J. Rosai and Ackerman’s surgical pathology. 9th ed. Mosby, Elsevier, St Louis, Missouri2004: 2462-2589
        • Li X.
        • Liu H.G.
        • Xie X.J.
        • et al.
        [Clinicopathologic study of sinonasal teratocarcinosarcoma and its contrast with olfactory neuroblastoma].
        Zhonghua Bing Li Xue Za Zhi. 2008; 37 ([in Chinese]): 458-464
        • Salem F.
        • Rosenblum M.K.
        • Jhanwar S.C.
        • et al.
        Teratocarcinosarcoma of the nasal cavity and paranasal sinuses: report of 3 cases with assessment for chromosome 12p status.
        Hum Pathol. 2008; 39: 605-609
        • Wang S.Y.
        • Zhu L.
        • Li S.M.
        • et al.
        [Sinonasal teratocarcinosarcoma: a clinical, radiologic and pathologic study of 5 cases].
        Zhonghua Bing Li Xue Za Zhi. 2007; 36 ([in Chinese]): 534-538
        • Wei S.
        • Carroll W.
        • Lazenby A.
        • et al.
        Sinonasal teratocarcinosarcoma: a report of a case with review of literature and treatment outcome.
        Ann Diagn Pathol. 2008; 12: 415-425
        • Nitsche M.
        • Hermann R.M.
        • Christiansen H.
        • et al.
        [Rationale for individualized therapy in sinonasal teratocarcinosarcoma: case report].
        Onkologie. 2005; 28 ([in German]): 653-656