Abstract
We describe an 11-year-old female patient who presented with a 7-day history of diplopia
and difficulty walking. On examination she had ataxia, areflexia and ophthalmoplegia,
and a diagnosis of Miller Fisher syndrome (MFS) was made after the exclusion of other
conditions. Monocyte chemotactic protein-1 (MCP-1) and interleukin (IL)-8 chemokine
levels in the cerebrospinal fluid (CSF) were significantly increased in the acute
phase. We believe MFS in this patient was due to both peripheral nervous system dysfunction,
and central nervous system (CNS) involvement. The cause of MFS in this patient was
suggested by the localized chemokine production in the CSF. The high expression of
MCP-1 and IL-8 chemokines suggest that macrophages and T cells may stimulate inflammation
of the CNS in MFS.
Keywords
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Article info
Publication history
Accepted:
March 30,
2009
Received:
March 5,
2009
Identification
Copyright
© 2009 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
