Abstract
This study was performed to determine the relationship between p57/Kip2 and the growth
of human astrocytomas. Immunohistochemical staining for p57/Kip2, p53, p16, and Ki67
antigen was performed on paraffin-embedded tissue specimens obtained from 36 patients
with astrocytoma. Expression of p57/Kip2, p53, p16, and Ki67 antigen was generally
increased in association with the astrocytoma tumor grade. Expression of p16 was higher
in patients whose tumors express p57/Kip2 in greater than 10% of tumor cells (p < 0.05). Expression of p53 also tended to be higher, but not to a statistically significant
extent, in patients whose tumors express p57/Kip2 in greater than 10% of tumor cells.
These findings suggest that p57/Kip2 inhibits the growth of human astrocytomas, and
may function in parallel with p16 and p53. However, p57/Kip2 is, by itself, insufficient
to arrest the cellular proliferation of human astrocytomas.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Clinical NeuroscienceAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Expression p57/Kip2 potently blocks the growth of human astrocytomas and induces cell senescence.Am J Pathol. 2000; 157: 919-932
- Inducible expression of p57/KIP2 inhibits glioma cell motility and invasion.J Neurooncol. 2004; 68: 217-223
- Molecular biology of human astrocytomas.Technol Cancer Res Treat. 2006; 5: 185-194
- Cyclin and cyclin-dependent kinase expression in human astrocytoma cell lines.J Neuropathol Exp Neurol. 1997; 56: 291-300
- Current concepts in neuro-oncology: the cell cycle-a review.Neurosurgery. 1997; 40: 1000-1015
- Cloning of p57/KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution.Genes Dev. 1995; 9: 639-649
- Cell-cycle inhibition by independent CDK and PCNA binding domains in p21/Cip1.Nature. 1995; 375: 159-161
- p57KIP2 is induced by MyoD through a p73-dependent pathway.J Mol Biol. 2006; 356: 578-588
- p53 Family members in myogenic differentiation and rhabdomyosarcoma development.Cancer Cell. 2006; 10: 281-293
- p57(KIP2) expression is related to carcinogenesis and tumor progression in laryngeal tissues.Acta Otolaryngol. 2006; 126: 301-305
- p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors.Dev Biol. 2006; 298: 22-31
- Expressions of the CIP/KIP family of CDK inhibitor proteins in primary intestinal large B-cell lymphomas: correlation with clinical outcomes.Pathol Res Pract. 2002; 198: 741-746
- Tumor suppressor gene methylation in follicular lymphoma: a comprehensive review.Mol Cancer. 2006; 6: 5-44
- Expression of p57/Kip2 protein in pancreatic adenocarcinoma.Pancreas. 2001; 23: 246-250
- Expression of p57/Kip2 protein in hepatocellular carcinoma.Oncology. 2001; 61: 221-225
- Expression of p57/Kip2 protein in normal and neoplastic thyroid tissue.Int J Mol Med. 2002; 9: 373-376
- Expression of p57/Kip2 protein in extrahepatic bile duct carcinoma and intrahepatic cholangiocellular carcinoma.Liver. 2002; 22: 145-149
- Expression of the components of the Cip/Kip family in malignant lymphoma of the thyroid.Pathobiology. 2004; 71: 164-170
- Immunohistochemical characterization of p57/Kip2 expression in human esophageal squamous cell carcinoma.Anticancer Res. 2000; 20: 1947-1952
- p57/KIP2, a structurally distinct member of the p21/CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.Genes Dev. 1995; 9: 650-662
- Downregulation of the KIP family members p27(KIP1) and p57(KIP2) by SKP2 and the role of methylation in p57(KIP2) inactivation in nonsmall cell lung cancer.Int J Cancer. 2006; 119: 2546-2556
- Multiplex short tandem repeat DNA analysis confirms the accuracy of p57(KIP2) immunostaining in the diagnosis of complete hydatidiform mole.Hum Pathol. 2006; 37: 1426-1434
- E proteins and Id2 converge on p57/Kip2 to regulate cell cycle in neural cells.Mol Cell Biol. 2006; 26: 4351-4361
- Loss of p53 function accelerates acquisition of telomerase activity in indefinite lifespan human mammary epithelial cell lines.Oncogene. 2003; 22: 5238-5251
Article info
Publication history
Accepted:
May 6,
2009
Received:
January 19,
2009
Identification
Copyright
© 2009 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
