Abstract
Most data regarding survival in patients with chondrosarcoma are limited to case studies
and small series performed at single institutions. A systematic review was performed
to study the relationship between potential prognostic factors and survival. The survival
rates were analyzed according to modality of treatment, treatment history, histological
subtype, and histological grade. A total of 560 patients with intracranial chondrosarcoma
were analyzed. Median follow-up time was 60 months. The 5-year mortality among all patients was 11.5% with median survival of
24 months. Mortality at 5 years was significantly greater for patients with tumors of higher grade, or of the
mesenchymal subtype, or who had received surgical resection alone. The results of
our systematic review provide useful data in predicting survival among intracranial
chondrosarcoma patients.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Clinical NeuroscienceAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Intracranial malignant cartilaginous tumours. Report of two cases and review of literature.Acta Neurochir (Wien). 1978; 45: 163-175
- Bone Tumors.Mosby, St. Louis1998
- Intracranial chondrosarcoma: review of the literature and report of 15 cases.J Neurol Neurosurg Psychiatry. 1998; 65: 88-92
- Fractionated proton radiation therapy of chordoma and low-grade chondrosarcoma of the base of the skull.J Neurosurg. 1989; 70: 13-17
- Chordomas and chondrosarcomas of the cranial base: results and follow-up of 60 patients.Neurosurgery. 1995; 36 (discussion 887–96): 887-896
- Chordoma and chondrosarcoma of the cranial base: an 8-year experience.Neurosurgery. 1989; 25 (discussion 931–40): 931-940
- Chondrosarcoma of the skull base: a series of eight cases.Neurosurgery. 1993; 32 (discussion 346–55): 348-355
- Chondrosarcoma of the petrous apex. Dilemmas in diagnosis and treatment.J Laryngol Otol. 1997; 111: 368-371
- Chondrosarcoma of the temporal bone. Diagnosis and treatment of 13 cases and review of the literature.Cancer. 1986; 58: 2689-2696
- Extracranial skull base chondrosarcoma.Ear Nose Throat J. 1989; 68 (626–32, 635)
- Chondrosarcoma of the skull base.J Neurooncol. 2006; 76: 49
- Intracranial mesenchymal chondrosarcoma.Acta Neuropathol. 1973; 24: 86-89
- Chondroid chordomas and low-grade chondrosarcomas of the craniospinal axis. An immunohistochemical analysis of 17 cases.Am J Surg Pathol. 1992; 16: 1144-1152
- Parasellar chondrosarcoma - case report.Neurol Med Chir. 1986; 26: 44-48
- Primary cranial and intracranial chondrosarcoma.A survey. Acta Neurochir. 1985; 78: 123-132
- Cranial chondrosarcoma. Report of four cases and review of the literature.Radiology. 1977; 124: 151-156
- The endoscopic transnasal transsphenoidal approach for the treatment of cranial base chordomas and chondrosarcomas.Neurosurgery. 2006; 59: ONS50-ONS57
- Cochlear implantation with ipsilateral petroclival chondrosarcoma.Otol Neurotol. 2006; 27: 337-341
- Management of cranial base chondrosarcoma.Neurosurgery. 2006; 58: 249-255
- Mesenchymal chondrosarcoma of the sellar region.Acta Neurochir (Wien). 2003; 145: 593-597
- Chondrosarcoma of the skull base.Laryngoscope. 2002; 112: 134-139
- A multidisciplinary team approach to skull base chondrosarcomas.J Neurosurg. 2001; 9: 184-189
- Radiation-induced tumors of the central nervous system occurring in childhood and adolescence. Four unusual lesions in three patients and a review of the literature.Childs Nerv Syst. 2000; 16: 390-397
- Combined transpetrosal-subtemporal craniotomy for clival tumors with extension into the posterior fossa.Laryngoscope. 1995; 105: 975-982
- Successful chemoradiation therapy for high-grade skull base chondrosarcoma in a child.Childs Nerv Syst. 1995; 11: 250-253
- Low-grade myxoid chondrosarcoma of the temporal bone: differential diagnosis and report of two cases.Am J Otol. 1994; 15: 419-422
- Chondrosarcoma of the skull base: a series of eight cases.Neurosurgery. 1993; 32: 348-355
- Skull base dumbbell tumor: surgical experience with two adolescents.Ann Otol Rhinol Laryngol. 1992; 101: 939-945
- Chondrosarcoma of the temporal bone in an infant: case report and review of the literature.Neurosurgery. 1992; 31: 956-957
- Chondrosarcoma of the skull base: report of six cases.Skull Base Surg. 1992; 2: 177-185
- Mesenchymal tumors of the skull base with particular reference to surgical management and outcome.Skull Base Surg. 1992; 2: 112-117
- The role of radiosurgery in the management of chordoma and chondrosarcoma of the cranial base.Neurosurgery. 1991; 29: 38-45
- Intracranial chondrosarcoma - case report.Neurol Med Chir. 1990; 30: 263-267
- Myxoid tumours in the temporal bone.J Laryngol Otol. 1989; 103: 1206-1209
- Chondrosarcoma of the posterior fossa - case report.Neurol Med Chir. 1989; 29: 1030-1038
- Extracranial skull base chondrosarcoma.Ear Nose Throat J. 1989; 68: 626-632
- Chondrosarcoma of the temporal bone. Diagnosis and treatment of 13 cases and review of the literature.Cancer. 1986; 58: 2689-2696
- Chondrosarcoma of the skull base.Otolaryngol Head Neck Surg. 1986; 94: 23-32
- Primary intracranial chondrosarcoma: a report of two cases.Neurosurgery. 1985; 17: 490-494
- Chondrosarcoma in the optic canal - a case report with ultrastructural study.Neurol Med Chir. 1985; 25: 36-41
- Intracranial chondrosarcoma: a case report and review of the literature.J Neurooncol. 2004; 68: 33-39
- Primary intracerebral mesenchymal chondrosarcoma with rhabdomyosarcomatous differentiation: case report and literature review.Br J Neurosurg. 2001; 15: 419-424
- Chondrosarcomas of the skull base: review of the literature and report of two cases.J Craniomaxillofac Surg. 1997; 25: 322-327
- Remitting sixth nerve palsy in skull base tumors.Arch Ophthalmol. 1993; 111: 1391-1395
- Successful treatment of a chemoresistant tumor with temozolomide in an adult patient: report of a recurrent intracranial mesenchymal chondrosarcoma.J Neurooncol. 2005; 71: 333-334
- Intracranial extraskeletal myxoid chondrosarcoma: case report and review of the literature.Acta Neurochir (Wien). 2002; 144: 735-740
- Parafalcine chondrosarcoma: an unusual localization for a classical variant. Case report and review of the literature.Surg Neurol. 2001; 55: 174-179
- Intracranial mesenchymal chondrosarcoma in an infant.Med Pediatr Oncol. 2000; 34: 370-374
- Extraskeletal myxoid chondrosarcom of the falx.Neurosurgery. 1992; 31: 344-348
- Radiation-induced intracranial fibrochondrosarcoma.J Neurol. 1986; 233: 309-310
- Falcine chondrosarcoma: case report and literature review.Neurosurgery. 1985; 16: 412-415
- Intracranial meningeal chondrosarcoma - probably mesenchymal type.Aust N Z J Surg. 1984; 54: 387-390
- Radiation-induced cerebellar chondrosarcoma. Case report.J Neurosurg. 1984; 61: 174-177
- Primary intracranial mesenchymal chondrosarcoma: case report with review of the literature.Neurosurgery. 1982; 10: 105-110
- Primary non-skeletal intracranial cartilaginous neoplasms: report of a chondroma and a mesenchymal chondrosarcoma.J Neurol Neurosurg Psychiatry. 1970; 33: 469-475
- A radiosensitive chondrosarcoma of the sphenoid sinus and base of the skull. Report of a case.Laryngoscope. 1972; 82: 57-60
- Chondrosarcoma of the head and neck.Am J Surg. 1970; 120: 456-460
- Cartilaginous tumors of the base of skull.Am J Roentgenol Radium Ther Nucl Med. 1969; 105: 308-313
- Cavernous sinus exenteration for invasive cranial base tumors.Neurosurgery. 2003; 52: 772-780
- The transsphenoethmoid approach to the sphenoid sinus and clivus.Neurosurgery. 1992; 31: 1008-1014
- Chondrosarcoma with subarachnoid dissemination.J Pathol. 1972; 107: 59-61
- Sterotactic fractionated radiotherapy for chordomas and chondrosarcomas of the skull base.Int J Radiat Oncol Biol Phys. 2000; 47: 591-596
- Proton radiation therapy for chordomas and chondrosarcomas of the skull base.J Neurosurg. 1999; 91: 432-439
- Probable causes of recurrence in patients with chordoma and chondrosarcoma of the base of skull and cervical spine.Int J Radiat Oncol Biol Phys. 1993; 25: 439-444
- Definitive radiation therapy for chordoma and chondrosarcoma of base of skull and cervical spine.J Neurosurg. 1982; 56: 377-385
- Chondrosarcomas of the skull base and temporal bone.J Laryngol Otol. 2007; 121: 725-735
- Chondrosarcoma of the skull base: long-term follow-up.Otol Neurotol. 2006; 27: 981-991
- Chondrosarcomas of the temporal bone: presentation and management.J Laryngol Otol. 2004; 118: 551-555
- Unusual presentation of petro-clival chondrosarcoma: short report.J Clin Neurosci. 2004; 11: 539-542
- Primary intracranial myxoid chondrosarcoma: report of a case and review of the literature.J Korean Med Sci. 2003; 18: 301-307
- Pituitary chondrosarcoma: an unusual cause of a sellar mass presenting as a pituitary adenoma.J Clin Endocrinol Metab. 2001; 86: 386-391
- Intracranial low-grade chondrosarcoma with hyperostosis of the skull: a case report.J Neurooncol. 2000; 49: 249-254
- Recurrent chondrosarcoma of the cranial base: a durable response to ifosfamide-doxorubicin chemotherapy.J Neurooncol. 1999; 41: 281-283
- The subtemporal-transpetrous appraoch for excision of petroclival tumors.Am J Otol. 1996; 17: 773-779
- Presentation and management of uncommon lesions of the middle ear.Am J Otol. 1995; 16: 634-642
- Management of intracavernous tumours: an 11-year experience.Acta Neurochir Suppl (Wien). 1991; 53: 122-126
- Subtemporal-preauricular infratemporal fossa approach to large lateral and posterior cranial base neoplasms.J Neurosurg. 1987; 67: 488-499
- Operative management of tumors involving the cavernous sinus.J Neurosurg. 1986; 64: 879-889
- Carbon ion radiotherapy of skull base chondrosarcomas.Int J Radiat Oncol Biol Phys. 2007; 67: 171-177
- Chondrosarcoma of the base of the skull: a clinicopathologic study of 200 cases with emphasis on its distinction from chordoma.Am J Surg Pathol. 1999; 23: 1370-1378
- Primary parafalcine chondrosarcoma in a child.Acta Neuropathol. 1998; 95: 111-114
- Chondrosarcoma of the jugular foramen.Am J Otol. 1994; 15: 257-263
- BNCT for recurrent intracranial meningeal tumours - case reports.Acta Neurol Scand. 2007; 115: 243-247
- Intracranial extraskeletal mesenchymal chondrosarcoma: case report.Neurosurgery. 2000; 46: 207-211
- Extracranial skeletal metastases from an intracranial meningeal chondrosarcoma. Case report.J Neurosurg. 1974; 40: 651-653
- Intracranial chondrosarcoma with extracranial metastases. Case report.J Neurosurg. 1972; 36: 790-794
- Mesenchymal chondrosarcoma of the craniocervical junction.Clin Neurol Neurosurg. 1990; 92: 343-347
- Intracranial mesenchymal chondrosarcoma with osteoid formation: report of a pediatric case.Childs Nerv Syst. 2003; 19: 680-682
- Chondrosarcoma of the head and neck.World J Surg. 1992; 16: 1010-1015
- Exposure to midline cranial base without a facial incision through a combined craniofacial-transfacial procedure.Neurosurgery. 2005; 56: 28-35
- Chondrosarcoma of the head and neck.Laryngoscope. 1984; 94: 1529-1544
- Particle beam therapy for head and neck tumors: radiographical basis and clinical experience.Head Neck. 2006; 28: 750-760
- Endoscopic treatment of the isolated sphenoid sinus lesions.Eur Arch Otorhinolaryngol. 2005; 262: 142-147
- Primary chondrosarcoma of the head and neck in pediatric patients: a clinicopathologic study of 14 cases with a review of the literature.Cancer. 2000; 88: 2181-2188
- Cranial and intracranial cartilaginous tumours.Clin Radiol. 1968; 19: 327-333
- Supratentorial cartilaginous tumors. (A report of 2 cases).Dis Nerv Syst. 1973; 34: 384-388
- Chondrosarcoma of the petrous apex. Dilemmas in diagnosis and treatment.J Laryngol Otol. 1997; 111: 368-371
- Chondrosarcoma at the skull base.Ann Otol Rhinol Laryngol. 1981; 90: 53-55
- The role of stereotactic radiosurgery in the treatment of malignant skull base tumors.Int J Radiat Oncol Biol Phys. 1997; 39: 977-981
- Case report 476: Chondrosarcoma of base of skull (CBS).Skeletal Radiol. 1988; 17: 208-211
- Intracranial mesenchymal chondrosarcoma.Am J Neuroradiol. 1987; 8: 1137-1138
- Intracranial chondrosarcoma.Acta Neurochir. 1997; 139: 156-157
- Trauma to the corpus callosum: MR features.Am J Neuroradiol. 1988; 9: 1129-1138
- A combined infratemporal and posterior fossa approach for the removal of giant glomus tumors and chondrosarcoma.Surg Neurol. 1987; 28: 423-431
- View from beneath - pathology in focus. Primary intracranial mesenchymal chondrosarcoma.J Laryngol Otol. 1989; 103: 545-549
- Conventional and perfusion MR imaging of parafalcine chondrosarcoma.Am J Neuroradiol. 2003; 24: 245-248
- Skull base chondrosarcoma originating from the petroclival junction.Otol Neurotol. 2005; 26: 1052-1060
- Chordomas of the skull base: follow-up review and prognostic factors.Neurosurg Focus. 2001; 10: E1
- Chondroma/Chondrosarcoma of the spine.Neurosurg Clin N Am. 2008; 19: 57-63
- Chondrosarcoma of the mobile spine: report on 22 cases.Spine. 2000; 25: 804-812
- Lesions of the petrous apex: diagnosis and management.Otolaryngol Clin North Am. 2007; 40: 479-519, viii
- Chondrosarcoma of the base of the skull: a clinicopathologic study of 200 cases with emphasis on its distinction from chordoma.Am J Surg Pathol. 1999; 23: 1370-1378
- Patient outcome at long-term follow-up after aggressive microsurgical resection of cranial base chondrosarcomas.Neurosurgery. 2006; 58 (discussion 1090–98): 1090-1098
- National cancer database report on chondrosarcoma of the head and neck.Head Neck. 2000; 22: 408-425
- Prognostic factors in chondrosarcoma of bone: a clinicopathologic analysis with emphasis on histologic grading.Cancer. 1977; 40: 818-831
- Cranial chordomas in children and adolescents.J Neurosurg. 1996; 84: 584-591
- Chordoma in childhood and adolescence. A clinicopathologic analysis of 12 cases.Arch Pathol Lab Med. 1993; 117: 927-933
- Cranial base chordomas.Clin Neurosurg. 1997; 44: 491-509
- Intracranial chordomas: a clinicopathological and prognostic study of 51 cases.J Neurosurg. 1993; 78: 741-747
- Chordoma and chondroid neoplasms of the spheno-occiput. An immunohistochemical study of 41 cases with prognostic and nosologic implications.Cancer. 1993; 72: 2943-2949
- Hearing preservation in vestibular schwannoma stereotactic radiosurgery: what really matters?.J Neurosurg. 2008; 109: 129-136
- The strengths and limitations of meta-analyses based on aggregate data.BMC Med Res Methodol. 2005; 5: 14
- Synthesizing medical evidence: systematic reviews and metaanalyses.Neurosurg Focus. 2005; 19: E5
Article info
Publication history
Accepted:
May 6,
2009
Received:
April 9,
2009
Identification
Copyright
Published by Elsevier Inc.