Clinical Study| Volume 16, ISSUE 12, P1578-1581, December 2009

Download started.


Solitary fibrous tumor


      Intracranial solitary fibrous tumors (SFT) are typically dural based, CD34-positive neoplasms of mesenchymal origin. Since they were first described in 1996 at the meninges, fewer than 100 SFT had been reported in both cranial and spinal compartments of the central nervous system. SFT can resemble other spindle cell tumors both radiologically and histopathologically, and differentiation can be best achieved through viewing their ultrastructure and using immunohistochemical techniques. In this report, we present four patients with SFT. Upon diagnosing two patients with SFT located in the cerebellopontine angle and parasagittal areas, we reviewed our pathological files and found two more patients; one having a parasagittal tumor and the other having a convexity tumor, that had been diagnosed with hemangiopericytoma. These tumours proved to be SFT after an immunohistochemical re-examination.


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Journal of Clinical Neuroscience
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Klemperer P.
        • Rabin C.B.
        Primary neoplasms of the pleura: a report of five cases.
        Arch Pathol. 1931; 11: 385-412
        • Bikmaz K.
        • Cosar M.
        • Kurtkaya-Yapicier O.
        • et al.
        Recurrent solitary fibrous tumour in the cerebellopontin angle.
        J Clin Neurosci. 2005; 12: 829-832
        • Chan J.K.C.
        Solitary fibrous tumor – everywhere and a diagnosis in vogue.
        Histopathology. 1997; 31: 568-576
        • Kim K.A.
        • Gonzales I.
        • McComb J.G.
        • et al.
        Unusual presentation of cerebral solitary fibrous tumors: report of four cases.
        Neurosurgery. 2004; 54: 1004-1009
        • Navashiro H.
        • Nagakawa S.
        • Osada H.
        • et al.
        Solitary fibrous tumor of the meninges in the posterior cranial fossa: magnetic resonance imaging and histological correlation: case report.
        Neurol Med Chir (Tokyo). 2000; 40: 432-434
        • Ogawa K.
        • Tada T.
        • Takahashi S.
        • et al.
        Malignant solitary fibrous tumor of the meninges.
        Virchows Arch. 2004; 444: 459-464
        • Rodriguez F.
        • Scheithauer B.W.
        • Ockner D.M.
        • et al.
        Solitary fibrous tumor of the cerebellopontine angle with salivary gland heterotopia.
        Am J Surg Pathol. 2004; 28: 139-142
        • Vallat-Decouvelaere A.-.V.
        • Dry S.M.
        • Fletcher C.D.M.
        Atypical and malignant solitary fibrous tumors in the extrathoracic locations. Evidence of their comparability to intra-thoracic tumors.
        Am J Surg Pathol. 1998; 22: 1501-1511
        • Zeitler D.M.
        • Kanowitz S.J.
        • Har-El G.
        Malignant solitary fibrous tumor of the nasal cavity.
        Skull Base. 2007; 17: 239-246
        • Carneiro S.S.
        • Scheithauer B.W.
        • Nascimento A.G.
        • et al.
        Solitary fibrous tumor of the meninges: a lesion distinct from fibrous meningioma. A clinicopathologic and immunohistochemical study.
        Am J Clin Pathol. 1996; 106: 217-224
        • Emiko H.
        • Kurimoto M.
        • Fukuda O.
        • et al.
        Recurrent intracranial solitary fibrous tumor initially diagnosed as hemangiopericytoma.
        Brain Tumor Pathol. 2007; 24: 31-34
        • Metellus P.
        • Bouvier C.
        • Guyotat J.
        • et al.
        Solitary fibrous tumors of the central nervous system: clinicopathological and therapeutic considerations of 18 cases.
        Neurosurgery. 2007; 60: 715-722
        • Kocak A.
        • Cayli S.R.
        • Sarac K.
        • et al.
        Intraventricular solitary fibrous tumor: an unusual tumor with radiological, ultrastructural, and immunohistochemical evaluation: case report.
        Neurosurgery. 2004; 54: 213-217
        • Nunez A.P.
        • Rivas J.J.
        • Ricoy J.R.
        • et al.
        Solitary fibrous tumor of the tentorium cerebelli: case report.
        J Neurosurg Sci. 2004; 48: 59-62
        • Caroli E.
        • Salvati M.
        • Orlando E.R.
        • et al.
        Solitary fibrous tumors of the meninges: report of four cases and literature review.
        Neurosurg Rev. 2004; 27: 246-251
        • Cummings T.J.
        • Burchette J.L.
        • McLendon R.E.
        CD34 and dural fibroblasts: the relationship to solitary fibrous tumor and meningioma.
        Acta Neuropathol. 2001; 102: 349-354
        • Martin A.J.
        • Fisher C.
        • Igbaseimokumo U.
        • et al.
        Solitary fibrous tumors of the meninges: case series and literature review.
        J Neurooncol. 2001; 54: 57-69
        • Perry A.
        • Scheithauer B.W.
        • Nascimento A.
        The immunophenotypic spectrum of meningeal hemangiopericytoma: a comparison with fibrous meningioma and solitary fibrous tumor of meninges.
        Am J Clin Pathol. 1991; 96: 25-31
        • Teranishi K.
        • Yamamoto T.
        • Nakao Y.
        • et al.
        Recurrent solitary fibrous tumor of the falx cerebri with intraventricular extension: case report.
        Neurol Med Chir. 2007; 47: 269-272
        • Tihan T.
        • Viglione M.
        • Rosenblum M.K.
        • et al.
        Solitary fibrous tumors in the central nervous system. A clinicopathological review of 18 cases and comparison to meningial hemangiopericytomas.
        Arch Pathol Lab Med. 2003; 127: 432-439
        • Weon Y.C.
        • Kim E.Y.
        • Kim H.J.
        • et al.
        Intracranial solitary fibrous tumors: imaging findings in 6 consecutive patients.
        Am J Neuroradiol. 2007; 28: 1466-1469
        • Nikas D.C.
        • Girolami U.D.
        • Folkerth R.D.
        • et al.
        Parasagittal solitary fibrous tumor of the meninges. Case report and review of the literature.
        Acta Neurochir (Wien). 1999; 141: 307-313
        • Suzuki S.O.
        • Fukui M.
        • Nishio S.
        • et al.
        Clinicopathological features of solitary fibrous tumor of the meninges: an immunohistochemical reappraisal of cases previously diagnosed to be fibrous meningioma or hemangiopericytoma.
        Pathol Int. 2000; 50: 808-817
        • England D.M.
        • Hochhlolzer L.
        • Mc Carhy M.J.
        Localized benign and malignant fibrous tumors of the pleura.
        Am J Surg Pathol. 1989; 13: 640-658
        • Castilla E.A.
        • Prayson R.A.
        • Stevens G.H.J.
        • et al.
        Brain-invasive solitary fibrous tumor of the meninges: report of a case.
        Int J Surg Pathol. 2002; 10: 217-221