This report documents changes to axonal excitability in motor nerves in acute camphor toxicity. Although there were no changes to indicate an alteration in resting membrane potential, there was an exaggerated response to hyperpolarising currents in both threshold electrotonus and the current–threshold relationship. These findings suggest a transient decrease in the hyperpolarisation-activated conductance (IH). This report demonstrates that recently developed techniques for measuring axonal excitability are readily applied in the acute care setting and can document subclinical abnormalities that could be relevant to the underlying pathophysiology.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Journal of Clinical Neuroscience
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Multiple measures of axonal excitability: a new approach in clinical testing.Muscle Nerve. 2000; 23: 399-409
- Changes in inward rectification in peripheral nerves in stroke.J Physiol. 2007; 581: 927-940
- Axonal changes in spinal cord injured patients distal to the site of injury.Brain. 2007; 130: 985-994
- Up-regulation of slow K+ channels in peripheral motor axons: a transcriptional channelopathy in multiple sclerosis.Brain. 2008; 131: 3062-3071
- Mutation in the Na+ channel subunit SCN1B produces paradoxical changes in peripheral nerve excitability.Brain. 2005; 128: 1841-1846
- Metabolism of camphors and related compounds.Biochem J. 1969; 113: 57-65
- Camphor activates and strongly desensitises the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism.J Neurosci. 2005; 25: 8924-8937
- Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin.Science. 2005; 307: 1468-1472
- TRP channels as cellular sensors.Nature. 2003; 426: 517-524
- The TRP superfamily of cation channels.Sci STKE. 2005; 272: re3
- Altered motor nerve excitability in end-stage kidney disease.Brain. 2005; 128: 2164-2174
- Conduction and excitability properties of peripheral nerves in end-stage liver disease.Muscle Nerve. 2007; 35: 730-738
- Nerve excitability changes in critical illness polyneuropathy.Brain. 2006; 129: 2461-2470
Accepted: January 21, 2009
Received: September 9, 2008
© 2009 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.