Abstract
Intraneural perineurioma is a rare tumour that affects peripheral nerves and, based
on its histological features, may be confused with hereditary motor and sensory neuropathies.
Detailed neuropathology, including immunoperoxidase stains and electron microscopy,
is vital to distinguish these conditions. We report two patients with intraneural
perineurioma that demonstrate salient features of this tumour. The first patient is
the longest reported follow-up of an intraneural perineurioma; extension of the lesion
was observed over 14 years. The second patient is an 11-year-old female whose treatment highlights some
of the controversy surrounding the management of these lesions, and the importance
of thorough macroscopic and microscopic assessment by pathologists, including the
status of surgical resection margins.
Keywords
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References
- Hereditary motor and sensory neuropathies: an overview of clinical, genetic, electrophysiologic and pathologic features.in: Dyck P.J. Thomas P.K. Peripheral Neuropathy. 4th ed. Elsevier Saunders Co., Philadelphia2005: 1623-1653
- Perineurioma.in: Louis D.N. Ohgaki H. Wiestler O.D. Cavenee W.K. WHO Classification of Tumours of the Central Nervous System. IARC Press, Lyon2007: 158-159
- Intraneural perineurioma. A clonal neoplasm associated with abnormalities of chromosome 22.Am J Clin Pathol. 1995; 103: 696-704
- Intraosseous intraneural perineurioma: a report of a case with morphological, immunohistochemical and FISH study.Med Oral. 2004; 9: 64-68
- Ultrastructural identification of a benign perineurial cell tumor.Cancer. 1978; 41: 1823-1829
Bilbao JM, Schmidt R, Hawkins C. Diseases of peripheral nerves. In: Love S, Louis DN, Ellison DW, editors. Greenfield’s Neuropathology. Vol. 2. 8th ed. London: Hodder Arnold; 2008. p. 1632–41.
- Radial nerve palsy owing to localised hypertrophic neuropathy (intraneural perineurioma) in early childhood.J Child Neurol. 2004; 19: 71-75
Cortes W, Cheng J, Matoub HS. Intraneural perineurioma of the radial nerve in a child. J Hand Surg [Am] 2005; 30:820-5.
Article info
Publication history
Accepted:
February 8,
2009
Received:
December 22,
2008
Identification
Copyright
© 2009 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
