Summary
Topical hemostatic agents are widely and safely used in neurosurgery. The purpose
of this study was to compare and analyse the early tissue reactions to two hemostatic
agents, oxidized regenerated cellulose and gelatin sponge, in rabbit brain by magnetic
resonance imaging and histopathologic sections. Bilateral identical parenchymal lesions
were made in the frontal regions of each hemisphere in 13 rabbits. Hemostasis was
achieved using oxidized regenerated cellulose or gelatin sponge, one agent being used
on each side. Cranial magnetic resonance imaging was performed 24 h postoperatively
and there was no statistical difference in edema formation at the site of the lesions.
Histopathologic examinations indicated that pericapillary edema and endothelial distortion
were common in both groups but that there was additional tissue degeneration evident
in the regions where gelatin sponge had been used. Oxidized regenerated cellulose
seemed to cause greater tissue distortion in magnetic resonance images than gelatin
sponge but in contrast, histological examination of lesions in which oxidized regenerated
cellulose had been used revealed less tissue degeneration than histopathologic examinations
of lesions in which gelatin sponge had been used.
Keywords
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Article info
Publication history
Accepted:
February 6,
2004
Received:
October 29,
2003
Identification
Copyright
© 2005 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
