Summary
This study was performed to determine whether increased ganglioside-specific T cell
reactivity can be detected in the peripheral blood of patients with Guillain–Barré
syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).
T cell responsiveness to the gangliosides GM1, GM3, GD1a, GD1b, GD3, GT1b, GQ1b and
sulphatide was assessed in peripheral blood mononuclear cells from untreated GBS patients
(57), CIDP patients (43), patients with other peripheral neuropathies (55) and healthy
control subjects (74) in a standard 6-day proliferation assay. Increased T cell reactivity
to GM1 occurred in GBS patients compared to healthy controls and patients with other
neuropathies. There was increased reactivity to GM3 in GBS patients compared to patients
with other neuropathies but not compared to healthy controls. The frequencies of increased
T cell reactivity to GM1 and GM3 in CIDP patients were intermediate between those
of GBS patients and controls. We suggest that T cell reactivity to gangliosides might
play a contributory role in the pathogenesis of GBS and perhaps CIDP.
Keywords
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Article info
Publication history
Accepted:
April 22,
2004
Received:
February 2,
2004
Identification
Copyright
© 2004 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
