Abstract
The interaction between genetic and environmental factors for PD was examined in a
Chinese population. It was found that although the intron 2 MAOB (GT)n repeat polymorphism was not associated with PD in the population, a relationship
might have been masked by the “protective effect” of tea drinking. In individuals
who did not drink tea (<1 cup/day), the possession of short length ⩽178bp (GT)n alleles conferred a borderline significant increased risk for PD (adjusted OR=1.47;
C.I.=1.03–2.1). As the extent of tea consumption increased, the association between
the ⩽178bp allele and PD disappeared. This result suggests that the MAOB gene may be associated
with PD in Chinese if the putative protective effect of tea drinking is taken into
account. The significance of this finding is unclear as the study may be limited because
of its marginal significance and limited numbers. However, it does demonstrate the
importance of considering putative positive and negative environmental risk factors
in any examination of genetic risk factors for PD.
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Article info
Publication history
Accepted:
August 20,
2002
Received:
December 17,
2001
Identification
Copyright
© 2003 Elsevier Science Ltd. Published by Elsevier Inc. All rights reserved.
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Access this article on ScienceDirectLinked Article
- Erratum to “Genetic and environmental risk factors and their interactions for Parkinson’s disease in a Chinese population” Journal of Clinical Neuroscience 2003; 10: 313–315Journal of Clinical NeuroscienceVol. 11Issue 2
