Advertisement

Non-neoplastic demyelinating process mimicking a disseminated malignant brain tumour

      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      Non-neoplastic demyelinating processes of the brain with ring enhancing lesions and mass effect on MRI imaging, mimicking malignant brain tumours, are rare phenomena.
      We document the case of a 32 year old male with clinical, radiological and initial histological findings, suggestive of a malignant brain tumour. Additional investigations confirmed the diagnosis of multiple sclerosis.
      This case is significant as the lesion could not be easily distinguished from a malignant brain tumour on imaging alone. Cases such as this illustrate the importance of considering a demyelinating process in the differential diagnosis of tumour-like brain lesions.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of Clinical Neuroscience
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Hauser SL
        • Bresnan MJ
        • Reinherz EL
        • Weiner HL
        Childhood multiple sclerosis: Clinical features and demonstration of changes in T-cell subsets with disease activity.
        Ann Neurol. 1982; 11: 463-468
        • Abbot RJ
        • Howe JG
        • Currie S
        • Holland I
        Multiple sclerosis plaque mimicking tumour on computer tomography.
        Br Med J. 1982; 285: 1616-1617
        • Nelson MJ
        • Miller SL
        • McLain W
        • Gold LH
        A Multiple sclerosis: Large plaque causing mass effect on and ring sign.
        J Comput Assist Tomogr. 1981; 5: 892-894
        • Van der Velden M
        • Bots GTAM
        • Endtz LJ
        Cranial CT in multiple sclerosis showing a mass effect.
        Surg Neurol. 1979; 12: 307-310
        • Hunter SB
        • Balinger WE
        • Rubin JJ
        Multiple sclerosis mimicking primary brain tumor.
        Arch Pathol Lab Med. 1987; 111: 468-646
      1. J Neurosurg. 1981; 55: 620-623
        • Landtblom AM
        • Sjoqvist L
        • Soderfeldt B
        • Nyland H
        • houmas KA
        Proton MR spectroscopy and MR imaging in acute and chronic multiple sclerosis-ring like appearances in acute plaques.
        Acta Radiol. 1996; 37: 278-287
        • Lecky B RF
        • Jeyagopal N
        • Smith E TS
        Cerebral CT lesions in multiple sclerosis mimicking multiple metastases.
        J Neurol Neurosurg Psychiatry. 1991; 54: 92
      2. Kasahata, N, Murayama, S, Shiota, J, A clinico-pathological study of so-called “acute multiple sclerosis” mimicking a brain tumour on the MRI findings Rinsho Shinkeigaku, 1999, 39, 327, 332

        • Salcman M
        Glioblastoma and malignant astrocytoma.
        in: Kaye AH Jaws Jr, AR Brain Tumors. 1995: 446-447
        • Schoenberg BS
        Multiple primary neoplasms and the nervous system.
        Cancer. 1977; 4: 1961-1967
        • Choucair AK
        Development of multiple lesions during radiation therapy and chemotherapy in patients with gliomas.
        J Neurosurg. 1986; 65: 654-658
        • Cader MZ
        • Winer JB
        Cavernous haemangioma mimicking multiple sclerosis.
        BMJ. 1999; June 12; 318: 1604-1605
        • Ruff RL
        • Petito CK
        • Rawlinson DG
        Primary cerebral lymphoma mimicking multiple sclerosis.
        Arch Neurol. 1979; 36: 598
        • Pell MF
        • Revesz
        • Thomas DG
        Multicentric malignant glioma.
        Br J Neurosurg. 1991; 5: 631-634
        • Kyritsis AP
        • Levin VA
        • Yunk WK
        • Leeds NE
        Imaging patterns of multifocal gliomas.
        Eur J Radiol. 1993; 16: 163-170
        • Leon-Sotomayor LA
        Posterior fossa tumor mimicking multiple sclerosis.
        South Med J. 1974; 67: 1485-1488
        • Krishna K
        • Toth C
        • Jay V
        Focal plaque of demyelination mimiking cerebral tumor in a pediatric patient.
        Pediatr Neurosurg. 1988; 29: 60-63
        • Honszarenko K
        • Fryze C
        • Nowacki P.
        • Osuch S.
        • Grzelec H.
        • Fabian A.
        Cavernous angioma of brain stem mimiking multiple sclerosis.
        Folia Neuropathol. 1955; 33: 4
        • Vrethem M
        • Thoumas KA
        • Hilman J
        Cavernous angioma of the brain stem mimicking multiple sclerosis.
        The New England Journal of Medicine. 1977; 336: 875-876