This paper is only available as a PDF. To read, Please Download here.
Abstract
We report a case of a 39-year-old caucasian healthy male physician who developed intense
and recurrent déjà vu experiences within 24h of initiating concomitant amantadine–phenylpropanolamine
treatment against influenza. Déjà vu experiences terminated on discontinuation of
medication. Findings in temporal epilepsy suggest that mesial temporal structures,
including hippocampus, are rel ated to paramnesic symptoms. On the other hand, previous
case reports have confirmed that both amantadine and phenylpropanolamine alone, and
particularly in combination, can induce psychotic symptoms due to their dopaminergic
activity. The authors sugges t that déjà vu experiences may be provoked by increased
dopamine activity in mesial temporal structures of the brain.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Clinical NeuroscienceAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Possible use of amantadine in depression.Pharmacopsychiatry. 1999; 32:: 47-55
- Clinical use of amantadine in brain injury rehabilitation.Brain Inj. 1994; 8: 709-718
- Effect of amantadine on sexual dysfunction in neuroleptic-treated male schizophrenic patients.Clin Neuropharmacol. 1998; 21: 355-357
- Stimulation of dopa decarboxylase activity in striatum of healthy human brain secondary toNMDA receptor antagonism with a low dose of amantadine.Synapse. 1999; 34: 313-318
- Mental side effects of amantadine therapy: its spectrum and characteristics in a normal population.J Clin Psychiatry. 1981; 42:: 345
- Phenylpropanolamine-induced psychosis: potential predisposing factors.Gen Hosp Psychiatry. 1994; 16: 358-360
- The psychology of déjà vu: have I been here before? Witwaterstrand University Press, Johannesburg1983
- Psychic seizures.in: Engel J Pedley TA Epilepsy: a comprehensive textbook. Volume 1. Lippincott-Raven, Philadelphia1997: 543-548
- Episodic psychic symptoms in the general population.Epilepsia. 1993; 34: 133-140
- Déjà vu as related to diagnostic categories in psychiatric and neurosurgical patients.J Nerv Ment Dis. 1968; 146: 161-164
- Déjà vu experiences and reduplicative paramnesia.Br J Psychiatry. 1992; 161: 565-568
- Structured Clinical Interview for DSM-IV Axis I Disorders – Patient Edition (SCID-I/P, Version 2.0, 4/97 revision). Biometrics Research Department, New York State Psychiatric Institute, New York1997
- Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II). Biometrics Research Department, New York State Psychiatric Institute, New York1997
- Development, reliability, and validity of a dissociation scale.J Nerv Ment Dis. 1986; 174: 727-735
- Psychotic episode related to phenylpropanolamine and amantadine in a healthy female.Gen Hosp Psychiatry. 1995; 17: 457-458
- Prediction of detached personality in healthy subjects by low dopamine transporter binding.Am J Psychiatry. 2000; 157: 290-292
- Ventral hippocampal dopamine D1and D2systems and spatial working memory in rats.Neuroscience. 1999; 89: 743-749
Article info
Publication history
Accepted:
June 8,
2000
Received:
April 20,
2000
Identification
Copyright
© 2001 Harcourt Publishers Ltd. Published by Elsevier Inc. All rights reserved.
